The Core Structure of Ginsenan PA, a Phagocytosis-Activating Polysaccharide from the Root of Panax ginseng

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概要

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• Controlled Smith degradation and limited hydrolysis of ginsenan PA, the main phagocytosis-activating polysaccharide isolated from the root of Panax ginseng C. A. MEYER, were performed. The reticuloendothelial system-potentiating and anti-complementary activities of the degradation products were investigated. Methylation analysis of the primary and secondary Smith degradation products indicated that the core structural features of ginsenan PA include a backbone chain mainly composed of β-1,3-linked D-galactose. Almost half of the galactose units in the backbone carry side-chains composed of β-1,6-linked D-galactosyl residues at position 6. Further 3,6-branching of D-galactose units was observed in a part of the side-chains. α-L-Arabinose units are connected mainly to the core galactose moieties via position 6. Removal of most of the arabinose units had a considerable effect on immunological activity.

• 社団法人日本薬学会の論文
• 1994-09-15

著者

• 清水 訓子

  Kyoritsu College Of Pharmacy

• 友田 正司

  Kyoritsu College of Pharmacy

• 権田 良子

  Kyoritsu College of Pharmacy

• 大原 直子

  Kyoritsu College of Pharmacy

• 平林 啓子

  Kyoritsu College of Pharmacy

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