Characterization of a Novel Heteroglucan from the Rhizome of Cnidium officinale Exhibiting High Reticuloendothelial System-Potentiating and Anti-complementary Activities

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概要

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• A novel β-heteroglucan, called cnidirhan SIIA, was isolated from the rhizome of Cnidium officinale MAKINO. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was more than 1×10^7. It was composed of D-glucose, D-galactose and L-arabinose in the molar ratio of 85 : 5 : 8,in addition to small numbers of O-acetyl groups. Methylation analysis and nuclear magnetic resonance studies indicated its main structural features composed of β-1,6-linked D-glucopyranosyl residues with both 3,6- and 4,6-branching points. In addition, it has both β-1,4-linked L-arabinopyranosyl and β-1,6-linked D-galactopyranosyl residues. The polysaccharide showed very pronounced reticuloendothelial system-potentiating activity in a carbon clearance test, as well as a marked anti-complementary activity.

• 社団法人日本薬学会の論文
• 1994-07-15

著者

• 清水 訓子

  Kyoritsu College Of Pharmacy

• 友田 正司

  Kyoritsu College of Pharmacy

• 権田 良子

  Kyoritsu College of Pharmacy

• 大原 直子

  Kyoritsu College of Pharmacy

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