カタプレス散の配合変化

概要

論文の詳細を見る
Apparent incompatibility of Catapres Fine Granules (0.015% clonidine hydrochloride), a centrally acting antihypertensive agent, with 51 drugs often used in combination was tested. Catapres wrapped manually with powder paper and that wrapped mechanically with laminated glacin paper were not moistened under medium conditions (20°, RH 75%) by themselves. Under the worst conditions (30°, RH 92%), thc product by mechanical wrapping showed a marked moistening tendency in 4 days and that by manual wrapping in 2 days. Upon mixing with each of the 51 drugs under medium conditions, moistening or coloring was observed on mechanically wrapped 3 drugs : Aspara K, Chondron and Diastase. Catapres by manual wrapping increased the moistening tendency when mixed with SM powder, Alumigel and calcium lactate. It was concluded that Catapres is stable under weather in Japan and suitable for dispensing in combination with most durgs.
日本医療薬学会の論文
1980-02-20