薬物の溶解を伴う界面移行および吸収挙動のモデル解析 : バイオアベイラビリティ評価手法へのアプローチ

概要

論文の詳細を見る
To examine interfacial transfer and absorption behaviors of drugs with the dissolution from compressed tablet, two reliable methods were preliminarily developed. One of the methods (S-L_w-L_o system) was constructed based upon an interfacial transfer of the drug from aqueous phase (L_w) to organic phase (L_o) with the dissolution in L_w. Another method (S-L_w-in situ system) was constructed based upon perfusing the drug solution in rat intestinal tract in situ with the dissolution of the drug in a reservior (L_w). The experiments were carried out by using benzoic acids and barbiturates as test compounds to survey the validity and reproducibility of the methods. The drug appearance in organic phase of S-L_w-L_o system (C_o) was well correlated with the drug disappearance in the reservior of S-L_w-in situ system, following the first order kinetics. The C_o value was found to be simply estimated from solubility and partition coefficient of drug. The results indicated that the methods developed here can afford a quantitative evaluation of drug absorption behavior with high precision and may extend to evaluation procedure of bioavailability.
公益社団法人日本薬学会の論文
1980-11-25