Preparation and Properties of Novel Trisubstituted N-Nitrosoureas which Decompose to Afford Triazenes and Nitro Compounds under Mild Conditions
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3,3-Diethyl-(IIa, b) and 3-methyl-3-(3-pyridylmethyl)-1-nitroso-1-tolylureas (IIc, d) were prepared from the corresponding ureas (Ia-d). 3,3-Dialkyl-1-(2-tolyl) nitrosoureas (IIa, c) decomposed to produce 3,3-dialkyl-1-(2-tolyl) triazenes (IIIa, c) at room temperature. On the other hand, 3,3-dialkyl-1-(4-tolyl) ureas (IIb, d) gave mainly the corresponding triazenes (IIIb, d) in protic solvents, although IIb, d gave 3,3-dialkyl-1-(2-nitro-4-tolyl) ureas (IVb, d) and the denitrosated products (Ib, d) in chloroform or carbon tetrachloride.
- 公益社団法人日本薬学会の論文
- 1985-02-25
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