P-5 新規抗腫瘍性抗生物質キガマイシン類の構造研究(ポスター発表の部)

概要

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In our screening for antitumor antibiotics, we have isolated five new antibiotics, kigamicins A (1), B (2), C (3), D (4) and E (5), from a culture broth of Amycolatopsis sp. ML630-mF1. Kigamicins showed antimicrobial activities against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. They showed a potent antitumor effect on several cell lines in vitro and in vivo. The planar structures of kigamicins were elucidated mainly by NMR analysis. Kigamicins (Fig. 1) contained polycyclic xanthone skeleton and one to four deoxy sugar moieties. The stereochemistry of 1, 3 and 4 was then established by spectroscopic methods, X-ray crystallographic analysis and chemical degradation studies. Thus we concluded that the absolute structures of kigamicins were depicted as shown in Scheme 1 having 12S, 14R, 15S, 20R, 26R configuration as well as the stereochemistry of deoxy sugars (D-amicetose and D-oleandrose).
天然有機化合物討論会の論文
2005-09-15