Alkinonase A and AF, New Alkaline Proteinases produced by Streptomyces violaceorectus
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概要
- 論文の詳細を見る
Alkaline proteinases, named alkinonase A and AF, are isolated from the cultured broth of Streptomyces violaceorectus. Both alkinonases show remarkably strong antiinflammatory activity for the carrageenin-induced edema. Alkinonase A and AF are belonging to a new type of alkaline proteinases of microbial origin. The effect of inhibitors on the proteolytic activity and the substrate specifities of alkinonases are resembled to that of the neutral proteinases of microbial origin and different from that of the alkaline proteinases of microbial origin. Production, isolation, purification, effect of pH on the proteolytic activity, pH stability, effect of temperature on the proteolytic activity, effect of inhibitors on the proteolytic activity, substrate specifities and anti-inflammatory activity for the carrageenin induced edema of alkinonases are described in this paper.
- 社団法人日本薬学会の論文
- 1972-02-25
著者
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梅沢 浜夫
微化研
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福田 頴穂
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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梅沢 浜夫
Institute of Microbial Chemistry
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浜田 雅
微生物化学研究所
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福田 頴穂
Pharmaceutical Institute, Hiroshima University School of Medicine
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福田 頴穂
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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中村 昭四郎
広島大学医学部総合薬学科
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松崎 明紀
Institute Of Chemical Pharmacology Banyu Pharmaceutical Co. Ltd.
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