Inhibitors of Aminopeptidase B Suppress the Development of Hypertension in Spontaneously Hypertensive Rats
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概要
- 論文の詳細を見る
In order to confirm the pathophysiological isgnificance of the dissociation between the plasma levels of aminopeptidases A and B in spontaneously hypertensive rats, we tested the effects of several enzyme inhibitors including inhibitors of aminopeptidase B on the course of hypertension in these rats. In addition to an ihibitor of angiotensin-converting enzyme, inhibitors of aminopeptidase B (arphamenine B and bestatin) significantly suppressed the development of hypertension in these animals. This finding may represent an important clue to the pathogenesis of essential hypertension.
- 公益社団法人日本薬学会の論文
- 1986-11-25
著者
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和田 孝雄
Institute Of Microbial Chemistry
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梅沢 浜夫
微化研
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青柳 高明
Institute of Microbial Chemistry
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小島 蕗子
Institute of Microbial Chemistry
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永井 真知子
Institute of Microbial Chemistry
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原田 滋子
Institute of Microbial Chemistry
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梅沢 浜夫
Institute of Microbial Chemistry
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青柳 高明
Department of Hygienic Chemistry, Showa College of Pharmaceutical Sciences
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八須 貢
Laboratories of Pharmacology and Toxicology, Meiji Seika Kaisha Ltd.,
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村田 信二郎
Laboratories of Pharmacology and Toxicology, Meiji Seika Kaisha Ltd.,
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村田 信二郎
Laboratories Of Pharmacology And Toxicology Meiji Seika Kaisha Ltd.
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青柳 高明
Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences
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八須 貢
Laboratories Of Pharmacology And Toxicology Meiji Seika Kaisha Ltd.
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