Dose-Dependent Enzyme Suppression in Spleen Induced by GMI (Monosialoganglioside 1) Administration to Mice
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概要
- 論文の詳細を見る
our previous studies suggested that the administration of exogenous gangliosides to the body modulates enzymatic networks in the brain. In the present study, we tested whether that is the case with another organ, spleen. By testing the dose response relationship, we found that there is a optimum dose for the effect of enzymatic modulation of GMI (monosialoganglioside 1) administration. Although the optimum level varied depending on each of the examined hydrolytic enzymes, it usually fell in the range around 50 μg/kg body weight. The findings led us to conclude that the enzyme-modulating actions of gangliosides come not merely from the bizarre actions in vivo of high molecular exogenous substances.
- 公益社団法人日本薬学会の論文
- 1992-07-25
著者
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和田 孝雄
Institute Of Microbial Chemistry
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竹内 富雄
Institute of Microbial Chemistry
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青柳 高明
Institute of Microbial Chemistry
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小島 蕗子
Institute of Microbial Chemistry
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永井 真知子
Institute of Microbial Chemistry
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原田 滋子
Institute of Microbial Chemistry
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永井 克孝
東大医生化学
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永井 克孝
The Tokyo Metropolitan Institute Of Medical Science
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青柳 高明
Department of Hygienic Chemistry, Showa College of Pharmaceutical Sciences
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小山内 たか
The Tokyo Metropolitan Institute of Medical Science
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青柳 高明
Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences
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