Distinct Effects of Clinically Used Anthracycline Antibiotics on ras Oncogene-Expressed Cells
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概要
- 論文の詳細を見る
Doxorubicin, pirarubicin, and FAD-104,but not aclarubicin or MX 2,flattened the morphology of NIH3T3 cells that had been transformed by human H-ras and K-ras. The effect appeared on almost all cells, as early as 2 d following exposure to the antibiotics at concentrations inhibiting cell growth by 50% or more. The morphological alteration accompanied other nornal cell phenotypes, such as the restoration of actin atress fibers, anchorage dependence of cell growth and an increase in nucleoside diphosphate (NDP) kinase activity. NIH3T3 cells transformed by src and other tumor cell lines responded less prominently, if at all.
- 公益社団法人日本薬学会の論文
- 1993-09-15
著者
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上原 至雅
国立予研・生物活性物
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竹内 富雄
Institute of Microbial Chemistry
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神戸 敏江
Showa College of Pharmaceutical Sciences
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堀 誠
Showa College of Pharmaceutical Sciences
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土屋 香誉子
昭和薬科大学
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高橋 良和
微生物化学研究所
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堀 誠
微生物化学研究所
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土屋 香誉子
Showa College of Pharmaceutical Sciences
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高橋 良和
Institute of Microbial Chemistry
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上原 至雅
Department of Bioactive Molecules, National Institute of Health
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