Increased γ-Aminobutyrate Aminotransferase Activity in Brain of Patients with Alzheimer's Disease
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概要
- 論文の詳細を見る
In order to search for more proximal factors in the pathogenesis of Alzheimer's disease, we studied the activities of various enzyme in the brains of patients, as well as control cases, by postmortem autopsy. In addition to the findings already known, such as the increase in prolyl endopeptidase (post-proline cleaving enzyme, PPCE) activity and the decrease in kallikrein activity, we found, anew, an increase in aminobutyrate aminotransferase (GABA-T) activity in the Alzheimer brain. This may be an important impetus for the reduction of γ-aminobutyric acid (GABA) in the brain, one of the neurotransmitters. It has to be determined whether the former two abnormalities offer a background for such an abnormality of the neurotransmitter.
- 社団法人日本薬学会の論文
- 1990-06-25
著者
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和田 孝雄
Institute Of Microbial Chemistry
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竹内 富雄
Institute of Microbial Chemistry
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広川 勝〓
Tokyo Metropolitan Institute Of Gerontology
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青柳 高明
Institute of Microbial Chemistry
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小島 蕗子
Institute of Microbial Chemistry
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永井 真知子
Institute of Microbial Chemistry
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原田 滋子
Institute of Microbial Chemistry
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高橋 浩士
Tokyo Metropolitan Institute of Gerontology
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積田 亨
Tokyo Metropolitan Institute of Gerontology
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青柳 高明
Department of Hygienic Chemistry, Showa College of Pharmaceutical Sciences
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青柳 高明
Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences
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