Increase in Aminobutyrate Aminotransferase and Cholineacetyltransferase in Cerebrum of Aged Rats

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概要

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• We previously reported an increase in aminobutyrate aminotransferase (GABA-T) activity in the cerebrum of Alzheimer patients. In the present study, we investigated whether such findings are common in the usual aging process as well. We examined the activity of various enzymes, which were examined in the previous study, in the cerebrum of Wistar-Kyoto rats and spontaneously hypertensive rats. In the two strains, we compared the enzyme activities between the two groups of animals, 5 weeks and 13 weeks of age. In both strains, the older animals had significantly higher activities of GABA-T and choline acetyltransferase (ChAc-T). In spite of other enzymatic changes coexisting, the above two enzymes were suggested by discriminant function analysis to be playing a major role in the multiple enzymatic changes in the cerebrum of the animals.

• 社団法人日本薬学会の論文
• 1990-06-25

著者

• 和田 孝雄

  Institute Of Microbial Chemistry

• 竹内 富雄

  Institute of Microbial Chemistry

• 広川 勝〓

  Tokyo Metropolitan Institute Of Gerontology

• 青柳 高明

  Institute of Microbial Chemistry

• 小島 蕗子

  Institute of Microbial Chemistry

• 永井 真知子

  Institute of Microbial Chemistry

• 原田 滋子

  Institute of Microbial Chemistry

• 青柳 高明

  Department of Hygienic Chemistry, Showa College of Pharmaceutical Sciences

• 青柳 高明

  Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences

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