Quantitative Analysis of Clebopride and Its Metabolites in Rat Blood by Acid Decomposition

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概要

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• 6-Chloro-m-anisidine was obtained as one of the products by the acidic decomposition of elebopride and its main metabolites (total CP). This degraded product after derivatized with heptafluorobutyric anhydride was measured by use of mass fragmentography. A good calibration curve was obtained in the range 2-80 ng/ml of clebopride in rat blood. The concentration of total CP in rat blood after intravenous (0.1 and 0.5 mg/kg) and oral (0.5 mg/kg) administration was determined by this method.

• 公益社団法人日本薬学会の論文
• 1981-05-23

著者

• 梅村 甲子郎

  School Of Pharmaceutical Science Toho University

• 村田 信二郎

  Laboratories of Pharmacology and Toxicology, Meiji Seika Kaisha Ltd.,

• 早坂 洋司

  Laboratory of Biopharmaceutics, Central Research Laboratories, Meiji Seika Kaisha, Ltd.

• 梅村 甲子郎

  Laboratory of Biopharmaceutics, Central Research Laboratories, Meiji Seika Kaisha, Ltd.

• 村田 信二郎

  Laboratories Of Pharmacology And Toxicology Meiji Seika Kaisha Ltd.

• 早坂 洋司

  Laboratory Of Biopharmaceutics Central Research Laboratories Meiji Seika Kaisha Ltd.

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• Quantitative Analysis of Clebopride and Its Metabolites in Rat Blood by Acid Decomposition

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