サフラマイシンAの抗腫瘍性 : 特にマウス尾静脈内持続注入法による治療の試み

スポンサーリンク

概要

• 論文の詳細を見る

• Saframycin A, an antitumor antibiotic whose structure is characterized by twin heterocyclic quinone skeletons and α-cyanoamine moiety, showed a lethal activity against HeLa S_3 cells. Prolongation of exposure period from 1 or 2hr to 10 days drastically decreased drug concentrations required for the same killing effect. Following the i. v. or i. p. administration of [^<14>C]tyrosine-labeled Saframycin A to tumor-bearing mice, the highest radioactivity was observed in the small intestine after 15-30 min. Within 1hr, 55-78% of the dosed radioactivity was recovered from the urine and feces. Radioactivity concentration in the tumor tissue was lower than that in the blood. Effects of Saframycin A on solid tumors were studied in mice bearing sarcoma 180. Saframycin A was administered i. p. from Day 1 through Day 7 and the therapeutic effect was assessed by the decrease in tumor weight on Day 21 and by body weight change between Day 0 and Day 21. Saframycin A produced a marked inhibition of tumor growth (T/C, 54-11%), while the effects on body weight were less pronounced (T/C, 94-43%). Different treatment regimens were introduced to tumor-bearing mice from Day 5 through Day 9 at fixed doses. Among i. p., s. c., and i. v. injections, i. v. injection was the most toxic, while continuous i. v. infusion for 6hr or for 5 days diminished the toxicity to almost the same extent as obtained with s. c. injection. In histological examinations, marked necrobiotic changes were noted as early as 2 days after treatment with continuous infusion.

• 千葉大学の論文

著者

• 新井 正

  Department of Antibiotics, Research Institute for Chemobiodynamics, Chiba University

• 新井 正

  Department Of Antibiotics Research Institute For Chemobiodynamics Chiba University

• 新井 正

  千葉大学生物活性研究所

• 石黒 公子

  千葉大学生物活性研究所抗生物質部

• 石黒 公子

  千葉県がんセンター

関連論文

• STRUCTURE OF SAFRAMYCIN D, A NEW DIMERIC ISOQUINOLINEQUINONE ANTIBIOTIC(Communications to the Editor)
• ソ連科学アカデミーのことなど(研究余話)
• 5. 難治性感染症(昭和46年度(1971)千葉大学医学部公開講座抄録集)
• 2-1 癌の化学療法 : 微生物学の分野から(2.化学療法の諸問題,昭和44年度(1969)千葉大学医学部公開講座抄録集)
• 80(PB2-10) Streptomyces hygroscopicus var. crystallogenesより得られる抗菌性物質(ポスター発表の部)
• 抗真菌化学療法剤としての抗生物質(よりすぐれた抗生物質を求めて)
• 抗真菌化学療法の基礎
• サフラマイシンAの抗腫瘍性 : 特にマウス尾静脈内持続注入法による治療の試み
• 5.真菌症の化学療法(真菌症と真菌中毒症)
• 55 新抗生物質Saframycin A,B,Cの構造
• Saframycin群抗生物質の質量分析
• 糖関連抗生物質のFDマススペクトロメトリ-
• 制癌物質のスクリ-ニング (微生物の生産物と医療-2-ユニ-クなスクリ-ニング法を求めて)
• 内臓真菌症化学療法剤の作用機作と耐性 (内臓真菌症) -- (治療の進歩)
• New Havenだより(海外だより)
• 抗真菌化学療法の基礎
• 糖関連抗生物質のFDマススペクトロメトリ-

もっと見る 閉じる

スポンサーリンク