ANTIVIRAL ACTIVITY OF POLYXOMOLYBDOEUROPATE PM-104 AGAINST HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
スポンサーリンク
概要
- 論文の詳細を見る
A polyoxomol ybdoeuropate PM-104 (NH_4)_<12>H_2[Eu_4(MoO_4)(H_2O)_<16>(Mo_7O_<24>)_4]・13H_2O was found to be a potent inhibitor of the growth of human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS). On the basis of TI_<50> [median cytotoxic concentration (CC_<50>)/median effective concentration (EC<_50>)], the in vitro anti-HIV-1 activity of PM-104 is favorably comparable to that of a heteropolyoxotungstate PM-19 K_7[PTi_2W_<10>O_<40>]・6H_2O, which is one of the most potent HIV-1 inhibitors among the polyoxometalates so far tested. The heteropolyoxomolybdate with a potent anti-HIV-1 activity is introduced for the first time in this communication.
- 公益社団法人日本薬学会の論文
- 1991-06-25
著者
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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井上 義雄
科学警察研究所
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Inouye Y
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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徳武 巧記
Institute Of Pharmaceutical Sciences
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井上 義雄
広島大学医学部
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吉田 哲也
広島大学医学部
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山本 章博
Terumo Corporation R And D Center
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山瀬 利博
Research Laboratory Of Resources Utilization Tokyo Institute Of Technology
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井上 義雄
Hiroshima University School of Medicine
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徳武 巧記
Hiroshima University School of Medicine
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吉田 哲也
Hiroshima University School of Medicine
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中村 昭四郎
Hiroshima University School of Medicine
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Yamase T
Research Laboratory Of Resources Utilization Tokyo Institute Of Technology
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中村 昭四郎
Institute Of Pharmaceutical Sciences
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