A New Group of Antibiotics, Hydroxamic Acid Antimycotic Antibiotics. IV. Structures of Enactins Ia, Ib_1,Ib_2 and Va
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概要
- 論文の詳細を見る
Structures of enactins Ia, Ib_1,Ib_2 and Va were determined by spectroscopic studies using their bis-2,4-dinitrophenyl derivatives. Both enactins and neoenactins contain L-serine to form the hydroxamic acid structure. Their physico-chemical and biological properties are closely related. The structures of neoenactin congeners have been previosuly reported and enactins Ia and Va are proved to be 19-hydroxyneoenactin B_2 and 14-dihydroneoenactin M_1,respectively. Both enactins Ib_1 and Ib_2 are determined to be 19-hydroxyneoenactin B_1 and considered to be diastereoisomers at the 19-position, though their steric structures at this positioin remain to be determined.
- 公益社団法人日本薬学会の論文
- 1991-06-25
著者
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中村 昭四郎
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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古川 淳
Institute of Applied Microbiology, The University of Tokyo
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古川 淳
Institute Of Applied Microbiology University Of Tokyo
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山本 克己
Institute of Pharmaceutical Scienses, Hiroshima University School of Medicine
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椎木 芳和
Institute of Pharmaceutical Scienses, Hiroshima University School of Medicine
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椎木 芳和
Institute Of Pharmaceutical Scienses Hiroshima University School Of Medicine
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中村 昭四郎
Institute Of Pharmaceutical Sciences
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中村 昭四郎
Institute Of Applied Microbiology University Of Tokyo
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山本 克己
Institute Of Pharmaceutical Scienses Hiroshima University School Of Medicine
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