Synthesis of Novel Octahydro-1,5-imino-3-benzazocin-4,7,10-trione Derivatives Having a Methyl Group at the C-2 Position as ABC Ring Models of Saframycins

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概要

• 論文の詳細を見る

• (Z)-3-(2,4,5-Trimethoxy-3-methylbenzylidene)-1,6-dimethylpiperazine-2,5-dione (7a) was prepared by a simple regioselective C-monomethylation of (Z)-4-(4-methoxybenzyl)-3-(2,4,5-trimethoxy-3-methylbenzylidene)-1-methyl-piperazine-2,5-dione (3) followed by deprotection. Compound 7a was also prepared from (S)-1,4-diacetyl-3-methylpiperazine-2,5-dione (8) and the benzaldehyde derivative (9) in five steps as an optically active form. It was shown to be a useful intermediate for the preparation of novel octahydro-1,5-imino-3-benzazocin-4,7,10-trione derivatives having a methyl group at the C-2 position, as ABC ring models of saframycins.

• 公益社団法人日本薬学会の論文
• 1997-07-15

著者

• Suzuki Rieko

  Meiji College Of Pharmacy

• Kubo Akinori

  Meiji College Of Pharmacy

• Saito Naoki

  Meiji College Of Pharmacy

• TANITSU Masa-aki

  Meiji College of Pharmacy

• BETSUI Tamaki

  Meiji College of Pharmacy

• Tanitsu Masaaki

  Meiji College of Pharmacy

関連論文

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• Synthetic Approaches toward Ecteinascidins. Part 2. Preparation of the ABCDE Ring System of Ecteinascidins Having Characteristic Substituents in Both Benzene Rings
• A Practical Synthesis of the ABC Ring Model of Ecteinascidins
• 15(I-1) Renieramycins, the cytotoxic bistetrahydroisoquinoline alkaloids, from the Thai marine sponge, Xestospongia sp.
• PB91 SYNTHETIC APPROACHES TOWARD SAFRAMYCIN A
• Synthesis of Novel Octahydro-1,5-imino-3-benzazocin-4,7,10-trione Derivatives Having a Methyl Group at the C-2 Position as ABC Ring Models of Saframycins
• Synthesis of 5,8- and 5,6-Quinolinediones Using Oxidative Demethylation with Cerium(IV) Ammonium Nitrate

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