Chiral Ligand-Controlled Asymmetric Conjugate Addition of α-Trimethylsilanylacetate to Acyclic and Cyclic Enones

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概要

• 論文の詳細を見る

• The reaction of lithium ester enolate with enones provides a challenge for chemoselectivity, that is, discrimination between a conjugate addition and a 1,2-addition. Asymmetric conjugate addition of a lithium enolate of α-trimethylsilanylacetate to acyclic and cyclic α,β-unsaturated ketones was mediated by an external chiral ligand to give the corresponding 1,4-adducts in good enantioselectivity of 74% and good chemoselectivity.

• 公益社団法人日本薬学会の論文
• 2004-01-01

著者

• 富岡 清

  京都大学大学院薬学研究科

• Tomioka K

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Tomioka Kiyoshi

  Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• IGUCHI Mayu

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Doi Hirohisa

  Graduate School of Pharmaceutical Sciences, Kyoto University

• HATA Seiji

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Hata S

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Doi Hirohisa

  Graduate School Of Pharmaceutical Sciences Kyoto University

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