Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N-Sulfinyl Imines

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概要

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• Enantiomerically enriched sulfonamides were synthesized by the radical addition of an acetal to enantiomerically pure N-sulfinyl imines using dimethylzinc–air and boron trifluoride diethyl etherate. Higher levels of stereocontrol were observed by using a mesitylenesulfinyl group. Furthermore, an amine and an amino alcohol with high enantiomeric purity were obtainable from the sulfonamide product.

• 公益社団法人　日本薬学会の論文

著者

• TOMIOKA Kiyoshi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Yamamoto Yasutomo

  Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• Yamada Ken-ichi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Akindele Tito

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Sejima Takumi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Maekawa Masaru

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Nakano Mayu

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Tomioka Kiyoshi

  Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• Yamada Ken-ichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Yamamoto Yasutomo

  Graduate School of Pharmaceutical Sciences, Kyoto University

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