Asymmetric Construction of Binaphthyl by the Chiral Diether-Mediated Conjugate Addition of Naphthyllithium to Naphthalenecarboxylic Acid 2,6-Di-t-butyl-4-methoxyphenyl Ester
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概要
- 論文の詳細を見る
Two ways for the synthesis of binaphthyl were examined based on a chiral ligand-mediated asymmetric conjugate addition of 1-naphthyllithium to naththalene-2-carboxylic acid 2,6-di-t-butyl-4-methoxyphenyl esters. The one pot method by conjugate addition-elimination gave a relatively higher enantioselectivity than the two step synthesis based on addition and subsequent oxidative aromatization.
- 公益社団法人 日本薬学会の論文
著者
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TOMIOKA Kiyoshi
Graduate School of Pharmaceutical Sciences, Kyoto University
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SHINDO Mitsuru
Institute for Medicinal Resources, University of Tokushima
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Shindo Mitsuru
Institute For Medicinal Resources University Of Tokushima
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Yamamoto Yasutomo
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Yamada Ken-ichi
Graduate School of Pharmaceutical Sciences, Kyoto University
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Tomioka Kiyoshi
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Yamada Ken-ichi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Yamamoto Yasutomo
Graduate School of Pharmaceutical Sciences, Kyoto University
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Shindo Mitsuru
Institute for Materials Chemistry and Engineering, Kyushu University
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