Mechanistic Aspects of Thiyl Radical-Promoted Acyl Radical Cyclization of Formylenoate-Cyclization versus Oxidation

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概要

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• Treatment of formylalkenoates 1 and 7 with 2,2'-azobis(2-methylpropanenitrile) (AIBN) in the presence of dioxygen gave oxygenated carboxylic acids 5, 6, 8, 9 instead of acyl radical cyclization products, through preferential reaction of the corresponding acyl radicals with dioxygen rather than intramolecular attack to an enoate moiety. The reaction of 1 with AIBN in the absence of dioxygen recovered starting 1 in 98% yield.

• 公益社団法人日本薬学会の論文
• 2005-05-01

著者

• Yoshikai Kazuya

  Graduate School Of Pharmaceutical Sciences Kyoto University

• NISHIMURA Katsumi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Tomioka Kiyoshi

  Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• HAYAMA Tomoharu

  Graduate School of Pharmaceutical Sciences, Kyoto University

• YAMADA Kenichi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Nishimura Katsumi

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Hayama Tomoharu

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Yamada Kenichi

  Graduate School Of Pharmaceutical Sciences Kyoto University

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