A Chiral Ligand-Mediated Asymmetric Addition of a Lithium BHA Ester Enolate to an Aldehyde

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概要

• 論文の詳細を見る

• The asymmetric reaction of a lithium enolate generated from a BHA (2,6-di-tert-buty-4-methoxyphenyl) propanoate was allowed to react with benzaldehyde in the presence of a diether-type chiral ligand affording the corresponding anti-aldol product in a moderate enantioselectivity. A tetradentate ligand induced better enantios-electivity albeit relative loss of anti-selectivity. A variation of lithiating amide agent affected the selectivity, indicating involvement of an amine as a component of the mixed aggregate. Absolute configuration of some of the aldol products was determined by standard transformations.

• 公益社団法人日本薬学会の論文
• 2002-08-01

著者

• 富岡 清

  京都大学大学院薬学研究科

• 野村 豊

  Department Of Applied Chemistry Faculty Of Engineering Saitama University

• Tomioka K

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Tomioka Kiyoshi

  Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• Nomura Y

  Faculty Of Pharmaceutical Sciences The University Of Tokyo

• IGUCHI Mayu

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Doi Hirohisa

  Graduate School of Pharmaceutical Sciences, Kyoto University

• NOMURA Yumiko

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• Doi Hirohisa

  Graduate School Of Pharmaceutical Sciences Kyoto University

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