Synthesis of 1,2-Disubstituted Naphthalones and Tetrahydronaphthalenes from Dihydronaphthalenes Obtained by Conjugate Addition of Organolithium Reagents to 2,6-Bis(tert-butyl)-4-methoxyphenyl Naphthalenecarboxylates
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概要
- 論文の詳細を見る
A method of the conversion of 2,6-bis(tert-butyl)-4-methoxyphenyl dihydronaphthalenecarboxylates into substituted naphthalenes and tetrahydronaphthalenes was developed. Aromatization of substituted dihydronaphthalenecarboxylates with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and subsequent treatment with ceric ammonium nitrate (CAN) gave the corresponding substituted naphthalenecarboxylic acid. Alternatively, hydrogenolysis and subsequent treatment with CAN provided a way to tetrahydronaphthalenemethanols in good yields.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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TOMIOKA Kiyoshi
Graduate School of Pharmaceutical Sciences, Kyoto University
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KOGA Kenji
Research and Education Center for Materials Science, Nara Institute of Science and Technology
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SHINDO Mitsuru
Institute for Medicinal Resources, University of Tokushima
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Shindo Mitsuru
Institute For Medicinal Resources University Of Tokushima
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Tomioka Kiyoshi
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Koga Kenji
Research And Education Center For Materials Science Nara Institute Of Science And Technology
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Shindo Mitsuru
Institute for Materials Chemistry and Engineering, Kyushu University
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