Asymmetric Addition Reaction of Phenyllithium to 1,2-Ethylenediimine with the Aid of A Chiral Ligand
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概要
- 論文の詳細を見る
The reaction of N, N"-bis(4-methoxyphenyl)ethylenediimine with phenyllithium, with the mediation of a chiral ligand, provided the addition products, (1R, 2R)-N, N"-bis(4-methoxyphenyl)-1,2-diphenylethanediamine of 67% ee and the meso-product, in a ratio of 41 : 59. The net reaction involves sequential double additions of phenyllithium. In the first addition a new chiral center is created, but with rather poor selectivity, and in the second addition kinetic discrimination takes place, giving the chiral double addition product.
- 公益社団法人日本薬学会の論文
- 1997-10-15
著者
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IIDA Akira
Graduate School of Pharmaceutical Sciences, Kyoto University
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Iida Akira
Graduate School Of Pharmaceutical Sciences Kyoto University
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TANIYAMA Daisuke
Graduate School of Pharmaceutical Sciences, Kyoto University
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KANAI Motomu
The Institute of Scientific and Industrial Research, Osaka University
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TOMIOKA Kiyoshi
Graduate School of Pharmaceutical Sciences, Kyoto University
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Kanai Motomu
The Institute Of Scientific And Industrial Research Osaka University
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Tomioka Kiyoshi
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Taniyama Daisuke
Graduate School Of Pharmaceutical Sciences Kyoto University
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