Synthesis of Nitrogen-Functionalized Cyclohexanes Using Chemoselective Conjugate Addition of Phenyllithium to Linear ω-Nitro-α,β,ψ,ω-Unsaturated Ester and Subsequent Stereoselective Intramolecular Nitro-Michael Cyclization
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概要
- 論文の詳細を見る
Nitrogen-functionalized cyclohexane derivatives with three contiguous chiral centers were synthesized by nitroalkene-selective conjugate addition of phenyllithium to a ω-nitro-α,β,ψ,ω-unsaturated ester and subsequent stereocontrolled intramolecular nitro-Michael cyclization with cesium fluoride and a quaternary ammonium bromide. The cyclohexanes were applicable to the total synthesis of α-, β- and γ-lycoranes.
- 公益社団法人日本薬学会の論文
- 2004-09-01
著者
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Yasuhara Tomohisa
School of Pharmacy, Kinki University
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Muraoka Osamu
School of Pharmacy, Kinki University
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Muraoka Osamu
School Of Pharmaceutical Sciences Kinki University
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TOMIOKA Kiyoshi
Graduate School of Pharmaceutical Sciences, Kyoto University
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NISHIMURA Katsumi
Graduate School of Pharmaceutical Sciences, Kyoto University
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OSAFUNE Emi
School of Pharmaceutical Sciences, Kinki University
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Osafune Emi
School Of Pharmaceutical Sciences Kinki University
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Tomioka Kiyoshi
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Tomioka Kiyoshi
Graduate School Of Pharmaceutical Sciences Kyoto University
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Nishimura K
Graduate School Of Pharmaceutical Sciences Kyoto University
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Nishimura Katsumi
Graduate School Of Pharmaceutical Sciences Kyoto University
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Yasuhara Tomohisa
School Of Pharmaceutical Sciences Kinki University
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