Chiral Amidophosphane–Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids

スポンサーリンク

概要

• 論文の詳細を見る

• A catalytic asymmetric conjugate arylation of acyclic α,β-unsaturated ketones with arylboronic acids was catalyzed by 3 mol% of chiral amidomonophosphane 1–rhodium(I) in the presence of potassium hydroxide in a mixture of 1,4-dioxane and water at 70 °C to afford 1,4-conjugate arylated acyclic ketones with high enantiomeric excess in high chemical yield. Thirteen examples of the reaction demonstrate the general applicability of the catalytic system.

• 公益社団法人　日本薬学会の論文

著者

• TOMIOKA Kiyoshi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Yamamoto Yasutomo

  Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• Yamada Ken-ichi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Tomioka Kiyoshi

  Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• Chen Qian

  The Academy of Fundamental and Interdisciplinary Science, Harbin Institute of Technology

• Kuriyama Masami

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Hao Xinyu

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Soeta Takahiro

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Yamada Ken-ichi

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Kuriyama Masami

  Graduate School of Biomedical Sciences, Nagasaki University

関連論文

• Asymmetric Addition Reaction of Phenyllithium to 1,2-Ethylenediimine with the Aid of A Chiral Ligand
• Synthesis of Nitrogen-Functionalized Cyclohexanes Using Chemoselective Conjugate Addition of Phenyllithium to Linear ω-Nitro-α,β,ψ,ω-Unsaturated Ester and Subsequent Stereoselective Intramolecular Nitro-Michael Cyclization
• Podophyllotoxin Aza-Anologue, A Novel DNA Topoisomerase II Inhibitor
• Stereoselective Formal Synthesis of (+)-Allokainic Acid via Thiol-Mediated Acyl Radical Cyclization
• Stereoselective Radical Addition of an Acetal to Sterically Tuned Enantiomerically Pure N-Sulfinyl Imines
• Asymmetric Construction of Binaphthyl by the Chiral Diether-Mediated Conjugate Addition of Naphthyllithium to Naphthalenecarboxylic Acid 2,6-Di-t-butyl-4-methoxyphenyl Ester
• Radical Reactions Initiated by Dimethylzinc
• An Approach to a Chiral Cycloalkanone-Mediated Asymmetric Epoxidation of Stilbene with Oxone^[○!R]
• Synthesis of 1,2-Disubstituted Naphthalones and Tetrahydronaphthalenes from Dihydronaphthalenes Obtained by Conjugate Addition of Organolithium Reagents to 2,6-Bis(tert-butyl)-4-methoxyphenyl Naphthalenecarboxylates
• THE CHIRAL LIGAND-CATALYZED ENANTIOSELECTIVE CONJUGATE ADDITION OF ORGANOLITHIUM TO BHA ENOATE
• Synthesis of Hypervalent Pentavalent Carbon and Boron Compounds
• Controlling Factors in Chiral Bisoxazoline-Catalyzed Asymmetric Lithium Ester Enolate-Imine Condensation Producing a β-Lactam
• Chiral Amidophosphane–Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids
• Unexpected Catalytic Behavior of Chiral Bisoxazoline in Asymmetric Reaction of Lithium Ester Enolate with Imine
• Efficient Chiral Amidophosphine Ligand for Copper-catalyzed Asymmetric Addition of Diethylzinc to N-Sulfonylimines
• Chiral Ligand-Controlled Asymmetric Conjugate Addition of α-Trimethylsilanylacetate to Acyclic and Cyclic Enones
• A Chiral Ligand-Mediated Asymmetric Addition of a Lithium BHA Ester Enolate to an Aldehyde
• P-487 ALKALOID SYNTHESIS BY CATALYTIC INTRAMOLECULAR AMINATION
• Mechanistic Aspects of Thiyl Radical-Promoted Acyl Radical Cyclization of Formylenoate-Cyclization versus Oxidation
• Catalytic Asymmetric Syntheses of ICI-199441 and CP-99994 Using Nitro-Mannich Reaction
• Development of efficient catalytic arylation of aldehydes with thioether-imidazolinium carbene ligands
• Electrochemical Oxidation of 1,2-Diols to α-Hydroxyketones in Water

もっと見る 閉じる

スポンサーリンク