Synthetic studies on the starfish alkaloid imbricatine. Construction of an ent-imbricatine framework
スポンサーリンク
概要
- 論文の詳細を見る
A chiral synthetic route to the amino esters 5 and 6, which contain the fundamental framework of ent-imbricatine (ent-3), has been developed as a prelude to the total synthesis of the starfish alkaloid imbricatine (3). The route started from the sulfur-containing L-phenylalanine derivative 7 and proceeded through key steps such as cyclization of the amide 8 without racemization, reduction to the 1,3-cis-tetrahydroisoquinoline 9, and introduction of a chiral α-amino acid moiety into the chloride 18 by the 'bis-lactim ether' method.
- 公益社団法人日本薬学会の論文
- 1999-01-15
著者
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IMASHO Masaaki
Faculty of Pharmaceutical Sciences, Kanazawa University
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Ohba Masashi
Faculty Of Pharmaceutical Sciences Kanazawa University
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Imasho Masaaki
Faculty Of Pharmaceutical Sciences Kanazawa University
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FUJII Tozo
Faculty of Pharmaceutical Sciences, Kanazawa University
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Fujii Tozo
Faculty Of Pharmaceutical Sciences Kanazawa University
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OHBA MASASHI
Faculty of Pharmaceutical Sciences, Kanazawa University
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