Purines. LXXVIII. An Alternative Synthesis of the Sea Anemone Purine Alkaloid Caissarone

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概要

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• An alternative synthesis of N^6,3,9-trimethyl-8-oxoadenine (caissarone) (7b) has been accomplished by regio-selective methylation of N^6,3-dimethyl-8-oxoadenine (9-demethylcaissarone) (5b), which was obtained by N(7)-oxidation of N^6,3-dimethyladenine (2b) with m-chloroperoxybenzoic acid followed by O-methylation with MeI and subsequent treatment with aqueous NaOH. The UV spectral data for the dimethylated 8-oxoadenine 5b and eight of its regioisomers, among with the O^8,9-dimethyl isomer 9 was prepared for the first time in the present work, are summarized.

• 公益社団法人日本薬学会の論文
• 1997-11-15

著者

• 藤井 澄三

  金沢大学薬学部

• Itaya T

  Faculty Of Pharmaceutical Sciences Kanazawa University

• ITAYA Taisuke

  Faculty of Pharmaceutical Sciences, Kanazawa University

• KANAI Tae

  Faculty of Pharmaceutical Sciences, Kanazawa University

• Kanai T

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Kanai Tae

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Itaya Taisuke

  Faculty Of Pharmaceutical Sciences Kanazawa University

• TAKADA Yasutaka

  Faculty of Pharmaceutical Sciences, Kanazawa University

• FUJII Tozo

  Faculty of Pharmaceutical Sciences, Kanazawa University

• Fujii Tozo

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Takada Y

  Rikkyo Univ. Tokyo Jpn

• Takada Yasutaka

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 藤井 澄三

  Shinshu Univ. Nagano Jpn

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