Synthesis and Structure of the Marine Ascidian 8-Oxoadenine Aplidiamine

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概要

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• Alkylation of 8-oxoadenosine (13) with 4-benzyloxy-3,5-dibromobenzyl bromide (20), followed by Dimroth rearrangement and acid hydrolysis, provided N-(3,5-dibromo-4-hydroxybenzyl)-8-oxoadenosine (15). The 2'-deoxy version of this reaction sequence accomplished the first synthesis of N-(3,5-dibromo-4-hydroxybenzyl)-8-oxodenine (16), which is the correct expression for marine ascidian purine aplidiamine.

• 公益社団法人日本薬学会の論文
• 1999-09-15

著者

• Itaya T

  Faculty Of Pharmaceutical Sciences Kanazawa University

• ITAYA Taisuke

  Faculty of Pharmaceutical Sciences, Kanazawa University

• KANAI Tae

  Faculty of Pharmaceutical Sciences, Kanazawa University

• Kanai T

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Kanai Tae

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Itaya Taisuke

  Faculty Of Pharmaceutical Sciences Kanazawa University

• HOZUMI Yoshitaka

  Faculty of Pharmaceutical Sciences, Kanazawa University

• OHTA Tomohisa

  Faculty of Pharmaceutical Sciences, Kanazawa University

• Ohta Tomohisa

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Hozumi Y

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Hozumi Yoshitaka

  Faculty Of Pharmaceutical Sciences Kanazawa University

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