Synthesis of (±)-(4aα,6α,7α,7aα)-hexahydro-6-hydroxy-7- methylcyclopenta[c]pyran-3(1H)-one, a structure common to abelialactone, Aglykon A1, and isoboonein
スポンサーリンク
概要
- 論文の詳細を見る
Synthesis of (±)-(4aα,6α,7α,7aα)-hexahydro-6-hydroxy-7- methylcyclopenta[c]pyran-3(1h)-one [(±)-1] has been achieved through an 8- step route starting from 6,7-dihydrocyclopenta-1,3-dioxin-5(4H)-one (4). The identities of synthetic (±)-1 with abelialactone, Aglykon A1, and isoboonein permitted the unequivocal assignment of this common structure and the relative stereochemistry to these cyclopentano-monoterpene lactones.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
-
Ohba Masashi
Faculty Of Pharmaceutical Sciences Kanazawa University
-
Fujii Tozo
Faculty Of Pharmaceutical Sciences Kanazawa University
-
Haneishi Tsuyoshi
Faculty Of Pharmaceutical Sciences Kanazawa University
関連論文
- Purines. LXXIX. Synthesis and Hydrolysis of 3-Methoxyadenine and Its N^6-Benzyl Derivative Leading to the Corresponding 2-Hydroxyadenines
- Purines. LXXVIII. An Alternative Synthesis of the Sea Anemone Purine Alkaloid Caissarone
- Purines. IXXVII. An Alternative Synthesis of N^6-Demethylcaissarone from 9-Methyl-8-oxoadenine by Regioselective N(3)-Methylation : Utilization of the N(7)-Benzyl and N(1)-Benzyloxy Groups as Control Synthons
- Purines. LXXVI. Alkylation of 8-Oxoadenine Derivatives : Syntheses of 3,7-Dialkyl-, 3,9-Dialkyl-, and 3,7,9-Trialkyl-8-oxoadenines
- Purines. LXXV. Dimroth Rearrangement, Hydrolytic Deamination, and Pyrimidine-Ring Breakdown of 7-Alkylated 1-Alkoxyadenines : N(1)-C(2) versus N(1)-C(6) Bond Fission
- Purines. LXXIV. Syntheses and Rearrangements of 8-Oxoadenines Monomethylated at the N^6-, 1-, and 3-Positions
- Purines. LXXII. Oxidation of N^6-Alkyladenines with m-Chloroperoxybenzoic Acid Leading to N^6-Alkyladenine 1-Oxides
- Purines. LXXI. Preparation and Alkylation of 7-Alkyladenine 1-Oxides : A General Synthesis of 1-Alkoxy-7-alkyladenines
- A straightforward preparation of chiral 5-(aminomethyl)oxazole derivatives from α-amino esters and α-lithiated isocyanides
- Quinolizidines. XXI. : Syntheses of (±)- and (-)-Alancines(Organic,Chemical)
- Purines. LXXIII. Syntheses of 8-Alkoxy- and 8-Hydroxy-3-alkyladenines from 3-Alkyladenine 7-Oxides through 7-Alkoxy-3-alkyladenines
- Quinolizidines. XXII. : An Extension of the "3-Acetylpyridine Route" to the Syntheses of 9-Hydroxy-10-methoxy- and 10-Hydroxy-9-methoxybenzo[a]quinolizidine-Type Alangium Alkaloids(Organic,Chemical)
- Synthetic studies on the starfish alkaloid imbricatine. Construction of an ent-imbricatine framework
- Synthesis of (±)-(4aα,6α,7α,7aα)-hexahydro-6-hydroxy-7- methylcyclopenta[c]pyran-3(1H)-one, a structure common to abelialactone, Aglykon A1, and isoboonein