Antioxidant Effects of Hydroxybenzalacetones on Peroxynitrite-Induced Lipid Peroxidation in Red Blood Cell Membrane Ghost and SOS Response in Salmonella typhimurium TA4107/pSK1002
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概要
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Antioxidant activity of a series of hydroxybenzalacetones was determined against peroxynitrite-induced lipid peroxidation in red blood cell membrane and SOS response through DNA damage in bacterial cells. Hydroxybenzalacetone derivatives with hydroxy, methoxy, ethoxy or methyl substitution were analyzed and found to be more effective than the water-soluble vitamin E analogue Trolox. The inhibitory effect against lipid peroxidation correlated well to that against the SOS response, which is dependent on decomposition of peroxynitrite by hydroxybenzalacetones outside of the cell membrane. The antioxidant activity was shown to correlate well with the electric parameter σ^+. Electron-donating substituents with more negative σ^+ values increased the potencies. The result suggests that hydroxybenzalacetones with more electron-donating substituents will protect tissue more effectively against oxidative stress.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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SAITO YUTAKA
Faculty of Pharmaceutical Sciences, Okayama University
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MOTOHASHI Noriko
Kobe Pharmaceutical University
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TAKAHASHI Ayumi
Kobe Pharmaceutical University
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YAMAGAMI Chisako
Kobe Pharmaceutical University
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Yamagami Chisako
Kobe Pharmaceutical Univ. Kobe Jpn
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Saito Yutaka
Faculty Of Engineering Kanazawa University
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Saito Yutaka
Faculty Of Pharmaceutical Science Okayama University
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