Hydrophobic Properties of Antimutagenic Benzalacetones and Related Compounds

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概要

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• The π values of benzalacetones (BZ) and trans-1,1,1-trifluoro-4-phenyl-3-buten-2-ones (TF) with a substituent on the benzene ring were analyzed by the directional Hommett-type treatment. The correlation equation showed that π_<BZ> and π_<TF> values are altered from the π value of monosubstituted benzenes, π_<PhX>, mainly by the change in the hydrogen bonding behavior of the variable substituent caused by the electron-withdrawing fixed substituent. The log k' values for BZ and TF derived from reversed-phase liquid chromatography (RPLC) were correlated with log P values determined by using different compositions of methanol-phosphate buffer (pH 7.4) as eluents. A good linear correlation was obtained at 50% methanol concentration.

• 公益社団法人日本薬学会の論文
• 1998-02-15

著者

• MOTOHASHI Noriko

  Kobe Pharmaceutical University

• YAMAGAMI Chisako

  Kobe Pharmaceutical University

• KISHIDA Nami

  Kobe Pharmaceutical University

• KA Shuei

  Kobe Pharmaceutical University

• HORIUCHI Motoko

  Kobe Pharmaceutical University

• Yamagami Chisako

  Kobe Pharmaceutical Univ. Kobe Jpn

• Horiuchi M

  Kobe Pharmaceutical University

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