In Vivo Tumor Accumulation of Arginine-Rich Cell-penetrating Peptides and Anticancer Drug Delivery

スポンサーリンク

概要

• 論文の詳細を見る
• 2012-03-01

著者

• Futaki Shiroh

  Institute For Chemical Research Kyoto University

• Nakase Ikuhiko

  Institute For Chemical Research Kyoto University

• Saji Hideo

  Department Of Cardiology Matsushita Memorial Hosipital

• Ueda Masashi

  Faculty Of Medicine Radioisotopes Research Laboratory Kyoto University Hospital Kyoto University

• KONISHI Yusuke

  Institute for Chemical Research, Kyoto University

• Konishi Yusuke

  Institute For Chemical Research Kyoto University

関連論文

• Noninvasive Evaluation of Regional Myocardial Perfusion with Positron Emission Computed Tomography : PANEL DISCUSSION ON PROGRESS IN NONINVASIVE CARDIAC DIAGNOSIS
• Development of a Radiolabeled Probe for Detecting Membrane Type-1 Matrix Metalloproteinase on Malignant Tumors
• Prominent Lectin-Like Oxidized Low Density Lipoprotein (LDL) Receptor-1 (LOX-1) Expression in Atherosclerotic Lesions Is Associated with Tissue Factor Expression and Apoptosis in Hypercholesterolemic Rabbits(Analytical Biochemistry)
• Distribution Profiles of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP), Matrix Metalloproteinase-2 (MMP-2) and Cyclooxygenase-2 (COX-2) in Rabbit Atherosclerosis : Comparison with Plaque Instability Analysis(Analytical Biochemistry)
• Chemical Control of Biological Activity and Biodistribution of Metal Compounds : Drug Design of Metal Complexes with Biological Activity and Target-Specific Biodistribution
• PJ-071 Expression of Lectin-like Oxidized LDL Receptor-1 in Atherosclerotic lesions : Comparison with Tissue Factor Expression and Apoptosis in WHHLMI Rabbits(Atherosclerosis, basic-8, The 71st Annual Scientific Meeting of the Japanese Circulation Society
• Performance assessment of O-18 water purifier
• Mechanisms of [2,3-Butanedione Bis(N^4-Dimethylthiosemicarbazone)] zinc(Zn-ATSM_2)-Induced Protection of Cultured Hippocampal Neurons Against N-Methyl-_D-Aspartate Receptor-Mediated Glutamate Cytotoxicity
• 5-[^I]Iodo-A-85380 : assessment of pharmacological safety, radiation dosimetry and SPECT imaging of brain nicotinic receptors in healthy human subjects
• Pharmacokinetic analysis of ^I-labeled medium chain fatty acid as a radiopharmaceutical for hepatic function based on beta-oxidation
• In Vivo Measurement of Presynaptic Zn^ Release during Forebrain Ischemia in Rats(Pharmacology)
• Real-time In-cell ^F NMR Study on Uptake of Fluorescent and Nonfluorescent ^F-Octaarginines into Human Jurkat Cells
• Transmission of Extramembrane Conformational Switch into Channel Current : Design and Construction of Artificial Metal-Gated Receptor Channel
• Radioimmunodetection of Membrane Type-1 Matrix Metalloproteinase Relevant to Tumor Malignancy with a Pre-targeting Method
• 1P248 逆ミセル構造を伴うペプチドの脂質二重膜透過の粗視化シミュレーションによる研究(生体膜・人工膜-ダイナミクス,第48回日本生物物理学会年会)
• 1P240 膜透過ペプチドのベシクル膜透過の粗視化シミュレーションによる研究(生体膜・人工膜-ダイナミクス,第48回日本生物物理学会年会)
• Brain Extraction of 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium Ion (HPP^+), a Neurotoxic Metabolite of Haloperidol : Studies Using [^3H]HPP^+
• Ginseng Pretreatment Protects against Transient Global Cerebral Ischemia in the Rat : Measurement of Local Cerebral Glucose Utilization by [^C]Deoxyglucose Autoradiography
• Protective Effect of Zinc Against Ischemic Neuronal Injury in a Middle Cerebral Artery Occlusion Model
• Delivery of Condensed DNA by Liposomal Non-viral Gene Delivery System into Nucleus of Dendritic Cells(Biopharmacy)
• Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
• Effect of Polyethyleneglycol Spacer on the Binding Properties of Nuclear Localization Signal-Modified Liposomes to Isolated Nucleus
• The Diagnostic Impact of ^Tc-Tetrofosmin Myocardial SPECT on Angiogenesis Between Bone Marrow-and Peripheral Blood-derived Mononuclear Cells in Ischemia-Reperfusion Model(Nuclear Cardiology 9 (I), The 69th Annual Scientific Meeting of the Japanese Ci
• Modulation of Alamethicin Assembly by Hybridization
• Preparation of Peptide Thioester Segments Using Fmoc-Solid-Phase Peptide Synthesis
• Involvement of Sulfated Glycosaminoglycans with the Internalization of Basic Peptides
• Application of Arginine-Rich RNA-Binding Peptides to Gene Delivery
• Characteristics of Membrane Permeable Arginine-Rich Peptides
• Intracellular Delivery of Synthetic Peptides Mediated by Tat-related Peptides
• Facile Solid-Phase Synthesis of Sulfated Tyrosine-Containing Peptides : Part II. Total Synthesis of Human Big Gastrin-II and Its C-Terminal Glycine-Extended Peptide(G34-Gly Sulfate)by the Solid-Phase Segment Condensation Approach^
• Synthesis of the Big-molecular-form CCK-peptide by a Thioester Segment Condensation Approach
• Oligoarginine-mediated Delivery of Bioactive Peptides into Living cells
• A New Approach for Metal-induced Switch Using Modified Cysteines
• Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells
• Design and Synthesis of Oligoarginine-Fluorescein Conjugates Possessing Novel Self-Cleavable Spacers as a Model for Effective Intestinal Absorption
• Facile One-Pot Modification with Oligoarginine for Intracellular Delivery
• Direct and Efficient Cytosolic Delivery Using Oligoarginine Vectors in the Presence of Pyrenebutyrate
• Counteranion-Mediated Delivery of Arginine-Rich Peptides into Living Cells
• Synthesis of Nonplanar Peptides Bearing the 7-Azabicyclo[2. 2. 1]heptane Skeleton, and the Possible Self-organized Structures
• Synthesis and Antinociceptive Activity of [D-Ala^2]Leu-Enkephalin Derivatives Conjugated with the Adamantane Moiety
• Stability and Self-Association of a Model Transmembrane Helix in Lipid Bilayers
• Design of Phosphopeptides Bearing Photo-cross-linker for the Analysis of In-cell Protein Recognition
• Membrane-Associated Proteoglycans and Cellular Uptake of Arginine-Rich Peptides
• Characterization of the Cellular Uptake of Arginine-rich Peptides
• Analysis of Sulfated Tyrosine-Containing Peptides by Liquid Secondary-Ion Mass Spectrometry with Constant Neutral-Loss (80 amu) Scanning
• Metal-Assisted Stabilization of the Channel Assembly of Alamethicin : Metal Coordination with an Additional Histidine Yields Extremely Stable Channels
• Enhanced Internalization of Arginine-rich Peptides by Fatty Acid Modification
• Fe(III)-mediated Modulation of Peptide Structure and Recognition
• Chemical Synthesis of Proteins Corresponding to the Zinc Finger Domain of Sp1
• Modification with Iminodiacetic Acids for Controlling the DNA Binding of GCN4-bZIP Protein by a Metal Ion
• Identification of a receptor responsible for cellular uptake of R12 peptide
• Direct penetration of arginine-rich peptides into cells accompanies dynamic alteration of membrane structures
• Efficient Cellular Uptake of Flock House Virus Derived Peptide
• Efficient Internalization of Flock House Virus-derived Peptide into Living Cells
• A method for selective isolation of N-terminal peptide from N-blocked protein by the combination of AspN digestion, transamination, and tosylhydrazine glass treatment
• Elucidating effects of amphipathic peptides on cell-membrane architecture
• Properties of modularly assembled zinc finger peptides for creation of engineered transcription regulators
• Metal-stimulated transcriptional control system using CDH_2-type zinc finger peptides
• Design and Creation of Metal-Responsive DNA-Binding Proteins
• Time-Dependent Analysis of Artificial Transcription Factors Based on Zinc Finger Peptides
• α,α-Disubstituted Amino Acids Bearing a Large Hydrocarbon Ring. Peptide Self-Assembly through Novel Hydrophobic Recognition
• The Effect of Octaarginine on the Translocation of Daunomycin-branched Polypeptide Conjugates
• 1A1724 膜透過ペプチドによる脂質二重膜の構造変化の膜曲げ弾性依存(生体膜・人工膜1(構造・物性、ダイナミクス),第49回日本生物物理学会年会)
• Elucidating the Effect of Epsin Derived Amphipathic Peptide on Cell-Membrane Architecture
• Metal-Mediated Leakage Control by Histidine-Containing Alamethicin Analogs
• Evaluation of [^I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor : Comparison among single-photon emission computed tomography/X-ray computed tomography imaging, autoradiography, and immunohistochemistry
• In Vivo Tumor Accumulation of Arginine-Rich Cell-penetrating Peptides and Anticancer Drug Delivery
• An Approach to Explore Proteins Involved in the Internalization of Arginine-Rich Peptides Using Photocrosslinking
• Topical Migration of Membrane-Associated Molecules Induced by Direct Influx of Arginine-Rich Peptides into Cells
• A New Method of Protein Cross-Linking for the Preparation of Deubiquitinating Enzyme Resistant Ubiquitin Dimer
• Creation of Artificial Epidermal Growth Factor Receptor Activated by Coiled-Coil Peptides
• Development of membrane type-1 matrix metalloproteinase-specific activatable fluorescent probe for malignant tumor detection
• Mechanisms of Efficient Cellular Uptake of Arginine-Rich Cell-Penetrating Peptides
• Bioinspired Mechanism for the Translocation of Peptide through the Cell Membrane
• In Vivo Evaluation of a Radiogallium-Labeled Bifunctional Radiopharmaceutical, Ga-DOTA-MN2, for Hypoxic Tumor Imaging

もっと見る 閉じる

スポンサーリンク