Prediction of Interindividual Variability in Pharmacokinetics for CYP3A4 Substrates in Humans
スポンサーリンク
概要
- 論文の詳細を見る
- 2010-08-25
著者
-
SUGIYAMA Yuichi
The University of Tokyo
-
SUGIYAMA Yuichi
Graduate School of Pharmaceutical Sciences, The University of Tokyo
-
Chiba Koji
Faculty Of Pharmacy Keio University
-
KATO Motohiro
Chugai Pharmaceutical Co., Ltd.
-
CHIBA Koji
Keio University
-
ITO Takashi
Daiichi Sankyo Co., Ltd.
-
KOUE Toshiko
Otsuka Pharmaceutical Co., Ltd.
-
Sugiyama Yuichi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
-
Koue Toshiko
Otsuka Pharmaceutical Co. Ltd.
-
Kato Motohiro
Pre-clinical Research Dept. Chugai Pharmaceutical Co. Ltd.
関連論文
- マイクロドーズ臨床試験 : ヒト血漿中ニカルジピン濃度測定及び代謝物の予測
- Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan
- Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan
- Effect of Aminoguanidine on Lipopolysaccharide-Induced Changes in Rat Liver Transporters and Transcription Factors(Molecular and Cell Biology)
- Function of Uptake Transporters for Taurocholate and Estradiol 17β-D-Glucuronide in Cryopreserved Human Hepatocytes
- Microdose clinical trial : Quantitative determination of fexofenadine in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry
- Potential Cholestatic Activity of Various Therapeutic Agents Assessed by Bile Canalicular Membrane Vesicles Isolated from Rats and Humans
- The Potential for an Interaction between MRP2 (ABCC2) and Various Therapeutic Agents : Probenecid as a Candidate Inhibitor of the Biliary Excretion of Irinotecan Metabolites
- Quantitative Prediction of In Vivo Drug-drug Interactions from In Vitro Data : Effects of Active Transport of Inhibitors into the Liver
- Differences in Substrate Specificity among Glutathione Conjugates (GS-X) Pump Family Members: Comparison between Multidrug Resistance-associated Protein and a Novel Transporter Expressed on a Cisplatin-resistant Cell Line (KCP-4)
- Carrier-Mediated Uptake of Grepafloxacin, a Fluoroquinolone Antibiotic, by the Isolated Rat Lung Cells
- Nitric Oxide and Peroxynitrite Regulate Transporter Transcription in Rat Liver Slices(Molecular and Cell Biology)
- High-Speed Data Position Detection Method Using Template Matching for Hologram Memory
- Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects
- Evaluation of Methods for Prediciting Drug-drug Interactions by Monte Carlo Simulation
- Lack of Contribution of P-Glycoprotein (P-gp) to Transport via the Mouse Blood-Cerebrospinal Fluid Barrier
- The role of breast cancer resistance protein, Bcrp in the transport of estrone-3-sulfate and dehydroepiandrosterone sulfate across the blood-brain barrier
- In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney
- Characterization of the Transport of a Cationic Octapeptide, Octreotide, In Rat Bile Canalicular Membrane : Possible Involvement of P-Glycoprotein
- Analysis of citrulline in rat brain tissue after perfusion with haloperidol by liquid chromatography-mass spectrometry
- Analysis of citrulline in rat brain tissue after perfusion with haloperidol by liquid chromatography-mass spectrometry
- Determination of 1-methyl-1,2,3,4-tetrahydroisoquinoline in mouse brain after treatment with haloperidol by gas chromatography-selected ion monitoring
- The Intestinal First-pass Metabolism of Substrates of CYP3A4 and P-glycoprotein-Quantitative Analysis Based on Information from the Literature
- Anti-metastatic Effect of the Sialyl Lewis-X Analog GSC-150 on the Human Colon Carcinoma Derived Cell Line KM12-HX in the Mouse
- Intestinal First-Pass Metabolism of CYP3A4 Substrates
- Prediction of Interindividual Variability in Pharmacokinetics for CYP3A4 Substrates in Humans
- Estimation of the Interindividual Variability of Cytochrome 2D6 Activity from Urinary Metabolic Ratios in the Literature
- Drug-drug interaction based on the inhibition on the transporter-mediated hepatic uptake (DRUG METABOLISM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Role of OATP transporter family in the hepatic uptake of pitavastatin (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Pharmacokinetics and Mechanism of Intestinal Absorption of JBP485 in Rats
- Species Difference in Nisoldipine Oxidation Activity in the Small Intestine
- First automatic radiosynthesis of ^C labeled Telmisartan using a multipurpose synthesizer for clinical research use
- Drug Transporters : Their Role and Importance in the Selection and Development of New Drugs