EFFECTS OF PRELOAD ALTERATION ON THE DEGREE OF ISCHEMIA AND FUNCTION OF ISCHEMIC MYOCARDIUM UNDER CONSTANT MEAN AORTIC PRESSURE, CORONARY PERFUSION PRESSURE AND HEART RATE IN ISOLATED PERFUSED CANINE HEART
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概要
- 論文の詳細を見る
We examined the effects of preload alteration on global and regional (i.e., non-ischemic and ischemic areas) function in the presence of regional myocardial ischemia and on the degree of ischemia using 18 isolated, metabolically supported canine left ventricles. For this purpose, cardiac output (CO), systolic segment length change (SL), myocardial CO_2 tension (PmCO_2) and ST level of epicardial ECG were measured at 3 levels of left ventricular end-diastolic pressure (LVEDP), i.e., approximately 7 (low LVEDP), 11 (middle LVEDP), and 16 mmHg (high LVEDP) without and with left circumflex artery (LCx) stenosis under a constant mean aortic pressure (90 mmHg), mean coronary perfusion pressure (90 mmHg) and heart rate. In the Pre-ischemic stage, CO and SL increased significantly when LVEDP was elevated in a stepwise fashion by changing the height of the reservoir connected to the left atrium. There were no significant changes in PmCO_2 or ST level. On the other hand, with LCx stenosis, CO did not show a subsequent SL response in the LCx area following alterations of LVEDP, although there was considerable lengthening of end-diastolic length. Both increased PmCO_2 and ST level of the LCx area, following LCx stenosis, further increased significantly with elevation of LVEDP. These results suggest the possibility that considerable elevation of LVEDP worsens the degree of ischemia and does not significantly augment ischemic regional myocardial function or global function, while mild elevation of preload improves or tends to improve simultaneously regional ischemic and global functions without aggravating the ischemic injury significantly. Therefore, we conclude that the preload level is quite important in managing ischemia induced myocardial dysfunction.
- 社団法人日本循環器学会の論文
- 1986-11-20
著者
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Takishima T
Department Of Cardiology Iwate Prefectural Central Hospital
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Maruyama Yukio
Fukushima Medical College
-
Takishima Tamotsu
The First Department Of Internal Medicine Tohoku University School Of Medicine
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Maruyama Yukio
The First Department Of Internal Medicine Tohoku University School Of Medicine
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Satoh Shoichi
Department of Internal Medicine, Kamaishi City Hospital
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Ino‐oka E
Hikarigaoka Spellman Hospital
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Ino-Oka Eiji
Hikarigaoka Spellman Hospital
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Maruyama Y
Tohoku Univ. Sendai Jpn
-
Isoyama S
The First Department Of Internal Medicine Tohoku University School Of Medicine
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Satoh S
Department Of Internal Medicine Kamaishi City Hospital
-
Satoh Syoichi
The First Department Of Internal Medicine Tohoku University
-
Satoh Shoichi
X Ray Research Laboratory Rigaku Corporation
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ISOYAMA SHOGEN
The First Department of Internal Medicine, Tohoku University School of Medicine
-
Inooka Eiji
Hikarigaoka Spellman Hospital
-
SATOH Shoichi
The First Department of Internal Medicine,Tohoku University School of Medicine
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Watanabe Jun
The First Department of Internal Medicine Tohoku University School of Medicine
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Ino-Oka Eiji
The First Dept. of Int. Med. Tohoku Univ.
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ASHIKAWA Kouichi
The First Department of Internal Medicine, Tohoku University School of Medicine
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SUZUKI Hideyuki
The First Department of Internal Medicine, Tohoku University School of Medicine
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NISHIOKA Osamu
The First Department of Internal Medicine, Tohoku University School of Medicine
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Satoh Syoichi
The 1st Dept. Of Internal Medicine Tohoku University School Of Medicine
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Ino-oka Eiji
The First Department Of Internal Medicine Tohoku University School Of Medicine
-
Inooka Eiji
1st Dept. Of Intern. Med. Tohoku Univ.
-
Maruyama Yukio
The First Department Of Internal Medicine Fukushima Medical College
-
Ino-oka Eiji
First Department Of Internal Medicine Tohoku University School Of Medicine Sendai
-
Ashikawa Koichi
The First Department Of Internal Medicine Tohoku University School Of Medicine
-
Nishioka Osamu
The 1st Departments Of Internal Medicine Tohoku University School Of Medicine
-
Sato Sotaro
The First Dep. Of Int. Med. Tohoku Univ. School Of Medicine Sendai
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Maruyama Y
東北大学 第1内科
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Isoyama Shogen
The 1st Dept. Of Int. Med. Tohoku Univ. School Of Med.
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In.oka Eiji
Hikarigaoka Spellman Hospital
-
Isoyama Shogen
The First Department Of Internal Medichine Tohoku University School Of Medicine
-
Takishima Tamotsu
The First Department Of Internal Medicine
-
Suzuki Hideyuki
The First Department Of Internal Medicine Tohoku University School Of Medicine
-
Maruyama Yukio
First Department Of Internal Medicine Tohoku University School Of Medicine Sendai Japan
-
Maruyama Yukio
The First Department Internal Medicine Fukushima Medical College
-
Maruyama Yukio
The First Departmenr Of Internal Medicine Tohoku University School Of Medicine
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