The Relationship between Lipoprotein Lipase Activity and Respiratory Quotient of Rats in Circadian Rhythms(Pharmacology)

スポンサーリンク

概要

• 論文の詳細を見る

• Plasma lipid levels and lipoprotein lipase (LPL) are known to follow circadian rhythms in rats. However, very little information is available on the variations in respiratory quotient (RQ) during the 24-h period in rats. The aims of this study were to provide an overall view of the effects of circadian rhythm on RQ and to determine the relationship of LPL and RQ with metabolic parameters in these animals. Male rats were fed ad libitum and were kept under a 12 : 12-h light-dark cycle. Rats were killed every 2h over a 24-h period for measurement of metabolic parameters and tissue LPL activity. The RQ was measured every 4h over the same 24-h period. The gastric contents increased during the dark phase and decreased during the light phase. For the metabolic parameters, circadian rhythms were detected for plasma glucose, triglycerides, high-density lipoprotein cholesterol and non esterified free fatty acids, but not for plasma total cholesterol or phospholipids. The RQ and adipose tissue LPL activity increased during the dark phase, while skeletal muscle LPL activity decreased during this phase. The RQ was inversely correlated with skeletal muscle LPL activity (r=-0.880) and positively correlated with adipose tissue LPL activity (r=0.937). These results appear to show that rats tend toward consumption of fat by accelerating fat oxidation, resulting in suppression of fat aceumulation in the light phase, while tending toward fat accumulation by the suppression of fat oxidation in the dark phase.

• 公益社団法人日本薬学会の論文
• 2002-10-01

著者

• Kondo Yasunori

  Nutrition Research Institute Otsuka Pharmaceutical Factory Inc.

• Inoue Yasuhide

  Nutrition Research Institute Otsuka Pharmaceutical Factory Inc.

• TSUTSUMI Kazuhiko

  Research and Development, Otsuka Pharmaceutical Factory, Inc.

• Tsutsumi Kazuhiko

  Research And Development Otsuka Pharmaceutical Factory

関連論文

• Amitriptyline-Induced Constipation in Cynomolgus Monkeys Is Beneficial for the Evaluation of Laxative Efficacy
• Low Molecular Weight Chitosan Prevents the Progression of Low Dose Streptozotocin-Induced Slowly Progressive Diabetes Mellitus in Mice
• New Model of Progressive Non-Insulin-Dependent Diabetes Mellitus In Mice Induced by Streptozotocin
• The Relationship between plasma High Density Lipoprotein Cholesterol Levels and Cholesteryl Ester Transfer Protein Activity in Six Species of Healthy Experimental Animals
• The Relationship between Lipoprotein Lipase Activity and Respiratory Quotient of Rats in Circadian Rhythms(Pharmacology)
• Suppression of Hyperlipidemia-Associated Cataracts in Diabetic Rats with the Lipoprotein Lipase Activator NO-1886
• Acceleration of Development of Diabetic Cataract by Hyperlipidemia and Low High-Density Lipoprotein in Rats

スポンサーリンク