Anti-ulcer Effect of Tea Catechin in Rats(Pharmacology)

概要

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Oral administration of tea catechin dose-dependently prevented absolute ethanol-induced (50, 100, 200mg/kg) or restraint plus water immersion stress-induced acute gastric mucosal injury (300, 400mg/kg) in rats. When the effect of test compound was evaluated on the 15th day after acetic acid injection to rats, repeated oral administration of tea catechin (25, 50, 100mg/kg twice daily) dose-dependently accelerated the healing of acetic acid-induced chronic gastric ulcers. Tea catechin (10^<-5>-10^<-1>g/100ml) concentration-dependency scavenged superoxide anions in vitro. Tea catechin (100, 200mg/kg orally) markedly inhibited the increase in thiobarbituric acid-reactive substances in the injured mucosa of rats treated with 50% ethanol. Tea catechin (50, 100mg/kg twice orally, daily) markedly inhibited the increase in content of thiobarbituric acid-reactive substances in the ulcerated region of acetic acid-induced gastric ulcers on the 7th and 15th days. In addition, at 50, 100 and 200mg/kg orally, it dose-dependently prevented the decrease in gastric mucosal hexosamine content induced by absolute ethanol, although it failed to inhibit the basal gastric acid secretion. These results suggest that tea catechin may primarily protect gastric mucosa from acute gastric mucosal injury and promote the healing of chronic gastric ulcers by its antioxidant activity and gastric mucus-increasing actions.
公益社団法人日本薬学会の論文
2006-11-01