Enhanced Adrenergic Response of the Cerebral Vasculature in Alloxan-Induced Diabetic Rats

元データ 公益社団法人日本薬学会

概要

The influence of alloxan-induced diabetes on the adrenergic constriction of the rat cerebral vasculature was investigated in the in situ perfused brain preparation. The preparation was perfused with an artificial medium at a constant flow rate and the change in perfusion pressure was measured. Norepinephrine (NE) and serotonin produced a dose-dependent increase in the perfusion pressure, but only the effect of NE was significantly enhanced in the diabetic rats. Such an enhancement of NE-induced vasoconstriction was not observed in the perfused hindquarter preparations from the diabetic rats. Propranolol (1 μM) potentiated the cerebrovascular constriction by NE and abolished the difference between diabetic and control rats at low doses of NE. However, vasoconstriction by the higher doses of NE in the diabetic rats was still enhanced even in the presence of propranolol. The cerebrovascular constriction by phenylephrine was also enhanced in the diabetic rats, while the vasoconstricting effects of clonidine, xylazine and oxymetazoline were not affected by diabetes. These results suggest that the enhanced cerebrovascular constriction by NE may be due to either the reduced response through β-adrenoceptors or the enhanced response through α_1-adrenoceptors. The enhanced adrenergic constriction of the cerebral vasculature might be concerned with the high incidence of neurological deficit in stroke patients with diabetes.

著者

KURIHARA Junichi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University
KATO Hitoshi Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University
Kato H Department Of Pharmacology Faculty Of Pharmaceutical Sciences Teikyo University
HOSONO Masahiro Pharmaceuticals Research Laboratories, Fujirebio Inc.
Hosono Masahiro Life Science Laboratories Central Research Laboratories Ajinomoto Co. Inc.:pharmaceuticals Research
Hosono Masahiro Pharmaceuticals Research Laboratories Fujirebio Inc.
Kato Hitoshi Department Of Pediatrics Kurume University School Of Medicine
HOSONO Masahiro Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University
Kurihara Junichi Department Of Pharmacology Faculty Of Pharmaceutical Sciences Teikyo University
Kato Hitoshi Department Of Pediatrics Graduate School Of Medicine University Of Tokyo
KATO Hitoshi Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo

関連論文

▼もっと見る