Successful Treatment of Class IV+V Lupus Nephritis with Combination Therapy of High-dose Corticosteroids, Tacrolimus and Intravenous Cyclophosphamide
スポンサーリンク
概要
- 論文の詳細を見る
A substantial number of patients with lupus nephritis (LN) are refractory to conventional glucocorticoid (GC) treatment. Although many of these patients respond to immunosuppressive drugs such as intravenous cyclophosphamide (IVCY), azathioprine (AZA), mizoribine, tacrolimus, cyclosporine A (CSA) and mycofenolate mofetil (MMF), some remain refractory to such therapies. Recent studies of multi-target therapies have reported effective outcomes for immunosuppression following renal transplantation and refractory LN when therapy consists of two or more immunosuppressive drugs with different mechanisms of action. We herein report a case of LN unresponsive to IVCY that was successfully treated with the addition of tacrolimus and discuss the usefulness of multi-target therapy for LN.
著者
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Ito Tatsuya
Department Of Cardiology Toyohashi Heart Center
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Amano Koichi
Department Of Rheumatology And Clinical Immunology Saitama Medical Center Saitama Medical University
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Nagasawa Hayato
Department Of Rheumatology And Clinical Immunology Saitama Medical Center Saitama Medical University
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Shibata Akiko
Department Of Prosthetic Dentistry Graduate School Of Biomedical Sciences Nagasaki University
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NISHIMURA Koji
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo
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KATO Hitoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Kurasawa Takahiko
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Nishi Eiko
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Takei Hirofumi
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Okuyama Ayumi
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Kondo Tsuneo
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Sakai Ryota
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Chino Kentaro
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Ogawa Hiroe
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Shibata Akiko
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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