Notable Difference between the Development of Vertebral Fracture and Osteonecrosis of the Femoral Head in Patients Treated with High-dose Glucocorticoids for Systemic Rheumatic Diseases
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概要
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Objective Vertebral fracture (VF) and osteonecrosis of the femoral head (OFH) are serious concerns in patients with rheumatic diseases treated with high-dose glucocorticoids (GCs). We comparatively examined the risk factors of VF and OFH in patients who had recently received high-dose GC therapy. Patients and Methods Patients with rheumatic diseases receiving GCs (≥0.5 mg/kg/day for prednisolone equivalent) within the past 2 months were enrolled in this study, and treated with 200 mg/day of etidronate cyclically. The bone mineral density (BMD) of the lumbar spine (L2-4) was examined by QDR2000. OFH was evaluated by magnetic resonance imaging (MRI). [ClinicalTrials.gov identifier: NCT00679978]. Results Forty-four patients completed the 2-year study including annual X-rays and the BMD analysis. MRI evaluation at entry and 2 years was performed in 41 patients. The BMD values with anteroposterior (AP) and lateral views decreased by 6.4% and 9.7%, respectively, in the first year, but were stable in the second year. Eleven patients developed VF and 9 patients developed OFH. The risk factors for VF included previous VF and a low BMD value (T score<-1.5) of AP view at baseline with an odds ratio (OR) of 14.9 (95%CI 2.9-76.4), while the risk factor for OFH was a recent maximum GC dosage (>1.2 mg/kg/day versus≤; OR=7.7, 95%CI 1.3-45.5) and a decrease in BMD value of lateral view (>15% versus≤; OR=6.7, 95% CI 1.2-36.1) in the first year. Conclusion The development of VF relies on the predisposing factors, while that of OFH depends on the response to high-dose GC therapy.
著者
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Kameda Hideto
Department Of Rheumatology And Clinical Immunology Saitama Medical Center Saitama Medical University
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Suzuki Katsuya
Department Of Ophthalmology Yokohama City University School Of Medicine
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Amano Koichi
Department Of Rheumatology And Clinical Immunology Saitama Medical Center Saitama Medical University
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Sekiguchi Naoya
Department Of Rheumatology And Clinical Immunology Saitama Medical Center Saitama Medical University
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Takeuchi Tsutomu
Department Of Astronomy Faculty Of Science Kyoto University
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Nagasawa Hayato
Department Of Rheumatology And Clinical Immunology Saitama Medical Center Saitama Medical University
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Takei Hirofumi
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Ogawa Hiroe
Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Japan
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Ogawa Hiroe
Department of Rheumatology/Clinical Immunology, Saitama Medical Center, Saitama Medical University
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Takei Hirofumi
Department of Rheumatology/Clinical Immunology, Saitama Medical Center, Saitama Medical University
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Kameda Hideto
Department of Rheumatology/Clinical Immunology, Saitama Medical Center, Saitama Medical University
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Amano Koichi
Department of Rheumatology/Clinical Immunology, Saitama Medical Center, Saitama Medical University
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