Inhibition of Encystation of Entamoeba invadens by Aphidicolin
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概要
- 論文の詳細を見る
Effects of aphidicolin, a specific inhibitor of eukaryotic nuclear replicative DNA polymerases, on the growth and encystation of a reptilian parasitic protozoan Entamoeba invadens were evaluated. Aphidicolin blocked the growth of axenic E. invadens strain IP-1 in a dose-dependent manner. Encystation induced by the glucose depletion and osmotic pressure was also inhibited by aphidicolin. The inhibition was almost complete when trophozoites were treated with the drug before being transferred to encystation medium containing the drug. The inhibitory effect of aphidicolin on E. invadens growth was abrogated by removal of the drug, and exposure to 3 μg/ml of the drug for at least 7 days had little effect on the viability. Encystation was also restored by removal of the drug. These results suggest that the trophozoites accumulated at G1/S border by treatment with aphidicolin cannot encyst upon induction of encystation so that they need DNA synthesis before encystation.
- 東海大学の論文
- 1998-08-29
著者
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Kobayashi Seiki
Department of Parasitology, School of Medicine, Keio University
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Takeuchi Tsutomu
Department of Parasitology, School of Medicine, Keio University
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Kobayashi Seiki
Department Of Parasitology School Of Medicine Keio University
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Takeuchi T
Department Of Tropical Medicine And Parasitology School Of Medicine Keio University
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MAKIOKA Asao
Department of Tropical Medicine, Jikei University School of Medicine
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OHTOMO Hiroshi
Department of Tropical Medicine, Jikei University School of Medicine
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KUMAGAI Masahiro
Department of Tropical Medicine, Jikei University School of Medicine
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Ohtomo Hiroshi
Department Of Tropical Medicine Jikei University School Of Medicine
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Takeuchi Tsutomu
Keio Univ. School Of Medicine Tokyo Jpn
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Makioka A
Jikei Univ. School Of Medicine Tokyo Jpn
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Makioka Asao
Department Of Tropical Medicine Jikei University School Of Medicine
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Ohtomo H
Department Of Tropical Medicine Jikei University School Of Medicine
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Kumagai Masahiro
Department Of Tropical Medicine Jikei University School Of Medicine
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Kumagai Masahiro
Department Of Oral And Maxillofacial Surgery Tohoku Kosai Hospital
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Takeuchi Tsutomu
Department Of Obstetrics And Gynecology Tokyo Rinkai Hospital
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Kobayashi Seiki
Keio Univ. School Of Medicine Tokyo Jpn
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Takeuchi Tsutomu
Department Of Astronomy Faculty Of Science Kyoto University
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OHTOMO Hiroshi
Department of Medical Zoology, Faculty of Medicine, Tokyo Medical and Dental University
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