Captopril Enhances Cardiac Vagal but Not Sympathetic Neurotransmission in Pithed Rats
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概要
- 論文の詳細を見る
The effect of captopril on neurally evoked bradycardia and tachycardia was investigated in pithed rats. Captopril enhanced the vagal nerve stimulation-evoked bradycardia. Angiotensin I reduced the vagal bradycardia, which was reversed by subsequent administration of captopril. Bradykinin did not affect the neurally evoked bradycardia. Captopril and angiotensin I affected neither the exogenous acetylcholine-evoked bradycardia nor the sympathetic nerve stimulation-evoked tachycardia. These results suggest that the interruption of angiotensin II formation by captopril causes less presynaptic inhibition of acetylcholine release via angiotensin II receptors without affecting cardiac sympathetic neurotransmission.
- 公益社団法人 日本薬理学会の論文
著者
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SUZUKI Shigeto
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University
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OKUBO Yoko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University
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Uezono Takashi
Department Of Legal Medicine Asahikawa Medical College
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Arai Takanori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Teikyo University
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Okubo Yoko
Department Of Ecological Engineering Toyohashi University Of Technology
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Suzuki Shigeto
Department Of Civil Engineering Technical College Yamaguchi University
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Kurihara Junichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Teikyo University
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TAKATA Yoshinobu
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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KATO Hitoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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