MK-801 Prevents the Post-Ischemic Cerebral Hypoperfusion, but Not the Dysfunction of the Vagal Baroreflex in Dogs.
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概要
- 論文の詳細を見る
Pretreatment with MK-801, a non-competitive <I>N</I>-methyl-D-aspartate (NMDA) antagonist, failed to protect the vagal component of reflex bradycardia from 5-min global cerebral ischemia in dogs under pentobarbital anesthesia. On the other hand, MK-801 completely prevented the development of the post-ischemic cerebral hypoperfusion without affecting the cerebral blood flow in sham-operated animals. The results suggest that NMDA receptors may participate in the development of the secondary disturbance of the cerebral circulation, but are not involved in the post-ischemic dysfunction of the baroreflex system.
- 公益社団法人 日本薬理学会の論文
著者
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Tamaoki Satoru
Department Of Molecular Design Institute Of Biomedicals & Bioengineering Tokyo Medical & Den
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Kurihara Junichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Teikyo University
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KATO Hitoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Sahara Tatsuhiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University
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