Protection by Halothane of the Vagal Baroreflex System from Transient Global Cerebral Ischemia in Dogs.
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概要
- 論文の詳細を見る
A possible cerebroprotective effect of halothane was investigated in a canine model of 5-min global cerebral ischemia. In pentobarbital-anesthetized dogs, additional inhalation of 0.5 to 1% halothane prior to ischemia prevented the post-ischemic dysfunction of the vagal component of reflex bradycardia. In contrast, pretreatment with thiopental at 10 mg/kg, i.v. failed to prevent it. The influence of ischemia in the absence of anesthetics was similar to that under barbiturate anesthesia. The results suggest that halothane, but not barbiturate, may actively protect the vagal baroreflex system from ischemia.
- 公益社団法人 日本薬理学会の論文
著者
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Kurihara Junichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Teikyo University
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KATO Hitoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Tomita Hiroshi
Department of Advanced Materials, University of Tokyo, Kashiwa, Chiba 277-8561
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Ochiai Nobuhiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University
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