Effect of Betaxolol on Aspartate Aminotransferase Activity in Hypoxic Rat Retina In Vitro
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概要
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We investigated the effect of betaxolol on the decrease of mitochondrial aspartate aminotransferase (mAAT) activity in rat retinas induced by hypoxia in vitro. It is reported that mAAT decreases in ischemic or hypoxic retina and that the decrease is caused by Ca2+-dependent proteases such as calpain. Betaxolol is a compound that has β1-adrenergic receptor blocking and voltage-dependent calcium channel blocking properties. The rat eye cups were maintained with Locke’s solution saturated with 95% air – 5% CO2. The eye cups were immersed in glucose-free Locke’s solution saturated with 95% N2 / 5% CO2 (hypoxic solution). Ninety minutes of hypoxia caused a 20% decrease in mAAT activity. The eye cups incubated with the hypoxic solution containing 1 mM EGTA, 10 μM MK-801 or 100 μM betaxolol were protected from the decrease in mAAT activity, so that the residual mAAT activity was 50%, 45% or 40%, respectively, compared to the eye cups incubated in hypoxic solution alone, which had a 100% decrease in mAAT activity. In addition, co-incubation with EGTA and betaxolol had a greater protective effect against the mAAT decrease than a single application. This additive effect of betaxolol was dose-dependent. These results suggested that betaxolol had a protective effect against the decrease of mAAT caused by hypoxia and indicated that betaxolol might inhibit the Ca2+ release from intracellular Ca2+ stores.
- 社団法人 日本薬理学会の論文
- 2002-10-01
著者
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TAMAI Makoto
Department of Ophthalmology Tohoku University School of Medicine
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Tamai M
Tohoku Univ. Sendai Jpn
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Takeda Misako
Department Of Ophthalmology Juntendo University School Of Medicine
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Tamai Makoto
Department Of Ophthalmology And Visual Science Tohoku University Graduate School Of Medicine
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Tamai M
Laboratory Of Soils And Plant Nutrition Faculty Of Agriculture Miyazaki University
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TOMITA HIROSHI
Department of Ophthalmology, Tohoku University, School of Medicine
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ISHIGURO SEI-ICHI
Department of Ophthalmology, Tohoku University School of Medicine
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ISHIGURO Seiichi
Department of Ophthalmology, Tohoku University School of Medicine
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Tomita Hiroshi
Biomedical Engineering Research Organization Tohoku University
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Ishiguro Seiichi
Department Of Ophthalmology Tohoku University School Of Medicine
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Ishiguro Seiichi
Department Of Ophthalmology Tohoku University School Of Medicine Tohoku University
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Tomita Hiroshi
Department Of Electrical Engineering Faculty Of Engineering Nagoya University:(present Address)canon
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Ishiguro Sei-ichi
Department Of Biochemistry And Biotechnology Division Of Cell Technology Faculty Of Agriculture And
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Tamai M
Biomedical Engineering Research Organization Tohoku University
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ENDO Satoko
Department of Ophthalmology, Tohoku University School of Medicine
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Endo Satoko
Department Of Ophthalmology Tohoku University School Of Medicine
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富田 浩史
Tohoku University Institute For International Advanced Interdisciplinary Research
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Tamai Makoto
Department Of Biofunctional Science Tohoku University Biomedical Engineering Research Organization
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Tomita Hiroshi
Department Of Electrical Engineering Faculty Of Engineering Mie University
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Tamai Makoto
Graduate School Of Medicine Tohoku University
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Tomita Hiroshi
Department of Advanced Materials, University of Tokyo, Kashiwa, Chiba 277-8561
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