Analysis and Improvement of the Synthesis of N^6-(2-Carboxyethyl)-NAD
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概要
- 論文の詳細を見る
Reaction products of NAD with 3-propiolactone at pH 6 showed that 3-propiolactone not only alkylates at the N-1 position of the adenine ring of NAD, but also reacts with other positions on NAD and its derivatives. Modifications other than the N-1 alkylation lowered the yield of N^6-(2-carboxyethyl)-NAD. To improve the selectivity of the reaction of NAD with 3-propiolactone, reaction conditions were examined. The reaction at pH 3.5 gave pure 1-(2-carboxyethyl)-NAD in a yield of 73%, and the overall yield of N^6-(2-carboxyethyl)-NAD was about 50%.
- 社団法人日本生物工学会の論文
- 1986-12-25
著者
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Yamada Yasuhiro
Department Of Biotechnology Osaka University
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Yamada Yasuhiro
Department Of Fermentation Technology Faculty Of Engineering Osaka University
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Nakamura A
Department Of Applied Physics Nagoya University
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NAKAMURA Akio
Department of Material Science, Japan Atomic Energy Research Institute
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Urabe I
Osaka Univ. Osaka Jpn
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Urabe Itaru
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Urabe Itaru
Department Of Biotechnology Faculty Of Engineering Osaka University
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Urabe Itaru
Dept. Biotech. Grad. Sch. Eng. Osaka Univ.
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Okada H
Kansai Univ. Osaka Jpn
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Okada H
Department Of Fermentation Technology Faculty Of Engineering Osaka University
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Okada H
Nagaoka Univ. Technol. Niigata Jpn
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Okada H
Nagoya City Univ. School Of Medicine Nagoya Jpn
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Okada H
Department Of Fermentation Technology Facutly Of Enginering Osaka Univeristy
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Okada Hirosuke
Department Of Fermentation Technology Faculty Of Engineering Osaka University
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Okada Hirosuke
Deparment Of Fermentation Technology Osaka University
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Urabe Itaru
Department Of Biotechnology Osaka University
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SAKAMOTO HITOSHI
Niigata Research Laboratory, Mitsubishi Gas Chemical Co., Inc.
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Yamada Yuzo
Department Of Fermentation Technology Faculty Of Engineering Osaka University
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Yamada Y
Department Of Physics Faculty Of Science Kyoto University
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Sakamoto Hitoshi
Niigata Research Laboratory Mitsubishi Gas Chemical Co. Inc.
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Yamada Yasuhiro
Department Of Agricultural Chemistry Faculty Of Agriculture University Of Tokyo
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Nakamura Akio
Department Of Information And Computer Sciences Saitama University
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