Successful treatment with infliximab and low-dose methotrexate in a Japanese patient with familial Mediterranean fever
スポンサーリンク
概要
- 論文の詳細を見る
We report a Japanese patient with familial Mediterranean fever (FMF) who was successfully treated with the anti-tumor necrosis factor (TNF)-α monoclonal antibody, infliximab, and low-dose methotrexate. This patient was diagnosed as having FMF based on periodic fever with polyarthralgia typical of this disease and heterozygous mutations in the MEFV gene. Conventional treatment, such as colchicine and reserpine, failed to sufficiently control the FMF attacks. After starting infliximab (3 mg/kg) and low-dose methotrexate (6 mg/week), the frequency of the FMF attacks dramatically decreased and the clinical effect has remained unchanged for longer than 1 year. Combination therapy with infliximab and low-dose methotrexate may be a potent therapeutic option for FMF patients, particularly when conventional treatment is ineffective or cannot be employed because of adverse events.
- JAPAN SOC INTERNAL MEDICINEの論文
著者
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Nakamura A
Department Of Applied Physics Nagoya University
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IKEDA Shu-ichi
Department of Medicine, Shinshu University School of Medicine
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Matsuda Masayuki
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Tazawa Ko-ichi
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Shimojima Yasuhiro
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Nakamura A
Department Of Applied Physics Fukuoka University
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Matsuda M
Department Of Biology School Of Medicine Kyorin University
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Shimojima Y
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Ikeda SI
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Tazawa KI
Department of Rheumatology and Collagen Disease, Shinshu University School of Medicine
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Nakamura Akinori
Department Of Internal Medicine Shinshu University School Of Medicine
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Matsuda Masayuki
Third Department Of Medicine Shinshu University School Of Medicine
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Matsuda Masayuki
The Department Of Neurology Saku Central Hospital
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Ikeda Shu-ichi
Department Of Internal Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Ikeda Shu-ichi
Department Of Neurology Shinshu University School Of Medicine
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Shimojima Yoshio
Third Department Of Medicine Shinshu University School Of Medicine
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Ikeda Shu-ihci
Dep. Of Medicine (neurology And Rheumatology) Shinshu Univ. School Of Medicine
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Matsuda Masayuki
Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Tazawa Ko-ichi
Department of Rheumatology and Collagen Disease, Shinshu University School of Medicine
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Matsuda Masayuki
Department of Rheumatology and Collagen Disease, Shinshu University School of Medicine
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Shimojima Yasuhiro
Department of Rheumatology and Collagen Disease, Shinshu University School of Medicine
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Nakamura Akinori
Department of Rheumatology and Collagen Disease, Shinshu University School of Medicine
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Ikeda Shu-ichi
Department of Rheumatology and Collagen Disease, Shinshu University School of Medicine
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