Leukoencephalopathy Induced by Low-dose Methotrexate in a Patient with Rheumatoid Arthritis
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概要
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We report a patient with rheumatoid arthritis (RA) who developed leukoencephalopathy while being treated with low-dose methotrexate (MTX). She suddenly developed loss of recent memory and left homonymous hemianopsia ascribable to the bilateral but right-predominant occipitotemporal lesions. Intravenous administration of dexamethasone and cessation of MTX quickly relieved her clinical symptoms. Low-dose MTX-induced leukoencephalopathy is a rare complication in RA, but is important with regard to the possibility of serious neurological sequellae.
著者
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Matsuda Masayuki
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Shimojima Yasuhiro
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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KINOSHITA Tomomi
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University
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Ikeda Shu-ichi
Department Of Internal Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Kishida Dai
Department Of Internal Medicine Center For Rheumatic Diseases Dohgo Spa Hospital
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Fukushima Kazuhiro
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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Fukushima Kazuhiro
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Hineno Akiyo
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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