Successful Treatment with Rituximab in a Patient with Stiff-Person Syndrome Complicated by Dysthyroid Ophthalmopathy
スポンサーリンク
概要
- 論文の詳細を見る
We report a patient with stiff-person syndrome and insulin-dependent diabetes mellitus with anti-glutamic acid decarboxylase (GAD) antibody, who suddenly complained of diplopia due to dysthyroid ophthalmopathy. Therapeutic efficacy of plasmapheresis and high-dose intravenous immunoglobulin was transient. After starting administration of rituximab, the patient showed obvious improvement of muscle spasms due to stiff-person syndrome and ophthalmoplegia following quick depletion of CD20-positive cells in peripheral blood. The anti-GAD and anti-thyroid antibodies decreased slowly. This drug might be a potent therapeutic option for refractory patients with stiff-person syndrome, particularly in those associated with dysthyroid ophthalmopathy.
- JAPAN SOC INTERNAL MEDICINEの論文
著者
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Morita Hiroshi
Department of Cardiology, Shingu Munichipal Hospital
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IKEDA Shu-ichi
Department of Medicine, Shinshu University School of Medicine
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Matsuda Masayuki
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Katoh Nagaaki
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Ishii Wataru
Department of Internal Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Matsuda Masayuki
Third Department Of Medicine Shinshu University School Of Medicine
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Matsuda Masayuki
The Department Of Neurology Saku Central Hospital
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Ikeda Shu-ichi
Department Of Internal Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Ikeda Shu-ichi
Department Of Neurology Shinshu University School Of Medicine
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Ikeda Shu-ihci
Dep. Of Medicine (neurology And Rheumatology) Shinshu Univ. School Of Medicine
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Morita Hiroshi
Department Of Applied Chemistry School Of Engineering Kanagawa University
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Matsuda Masayuki
Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Ishii Wataru
Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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