Serum Heart-Type Fatty Acid-Binding Protein Concentration Positively Correlates With the Length of Aortic Dissection
スポンサーリンク
概要
- 論文の詳細を見る
Background Patients with aortic dissection (AD) often demonstrate positive heart-type fatty acid-binding protein (H-FABP), but its significance is unclear. Methods and Results In 63 of 64 consecutive AD patients, the serum H-FABP concentration was measured and the H-FABP positive rate calculated (cutoff value: 6.2ng/ml) for each of following factors: (1) with or without dissection of the ascending aorta; and (2) a thrombosed false lumen;(3) length score;(4) presence of shock;(5) malperfusion of limbs;(6) ST elevation and/or depression on electrocardiogram; and (7) renal dysfunction. In total 36 AD patients had a positive H-FABP test. Statistically significant differences in the H-FABP positive rate were observed between those with and without ascending AD (76.7% vs 39.4%, p=0.003), and in the length score (p<0.001). Multivariate logistic regression test demonstrated that the most significant factor was the length score (odds ratio: 2.239 (95% confidence interval: 1.119-4.481), p=0.023). Moreover, a significant correlation was observed between length score and absolute H-FABP value (r=0.420, p=0.001). Conclusions In patients with AD, an increased serum H-FABP concentration is caused by the protein being released not only from the cardiac muscle but also from skeletal muscle, or possibly the aortic wall. Physicians using H-FABP for detection of myocardial injury need to be aware that patients with a long or ascending AD will show an elevation of H-FABP.
- 社団法人日本循環器学会の論文
- 2005-07-20
著者
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Hazui Hiroshi
Department of Emegency Medicine, Osaka Mishima Emergency and Critical Care Center
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Nishimoto Masayoshi
Department of Emegency Medicine, Osaka Mishima Emergency and Critical Care Center
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Ohishi Yasuo
Department of Emegency Medicine, Osaka Mishima Emergency and Critical Care Center
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Morita Hiroshi
Department of Cardiology, Shingu Munichipal Hospital
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HANAFUSA Toshiaki
First Department of Internal Medicine, Osaka Medical College
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Murai Motonobu
First Internal Medicine, Osaka Medical College
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Muraoka Hideyuki
Department of Emergency Medicine, Osaka Mishima Emergency and Critical Care Center
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Fukumoto Hitoshi
Department of Emergency Medicine, Osaka Mishima Emergency and Critical Care Center
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Murai Motonobu
Department of Emergency Medicine, Osaka Mishima Emergency and Critical Care Center
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Muraoka Hideyuki
Osaka Mishima Emergency and Critical Care Medical Center
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Negoro Nobuyuki
First Department of Internal Medicine, Osaka Medical College
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Muraoka Hideyuki
1st Department Of Internal Medicine Osaka Medical College
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Ohishi Yasuo
Department Of Emegency Medicine Osaka Mishima Emergency And Critical Care Center
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Takeshita Hitoshi
Department of Emergency Medicine, Osaka Mishima Emergency and Critical Care Center
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Morita Hiroshi
Department Of Emergency Medicine Osaka Medical College
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Hanafusa Toshiaki
First Department Of Internal Medicine Osaka Medical College
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Nishimoto Masayoshi
Department Of Emegency Medicine Osaka Mishima Emergency And Critical Care Center
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Nishimoto Masayoshi
Department Of Dermatology Kagawa Medical University
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Hazui Hiroshi
Department Of Emegency Medicine Osaka Mishima Emergency And Critical Care Center
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Fukumoto Hitoshi
Osaka Mishima Critical Care Medical Center
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Negoro Nobuyuki
1st Department Of Internal Medicine Osaka Medical College
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Negoro Nobuyuki
First Department Of Internal Medicine Osaka Medical College
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Murai Motonobu
First Internal Medicine Osaka Medical College
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Murai Motonobu
1st Department Of Internal Medicine Osaka Medical College
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Nishimoto Masayoshi
Department Of Thoracic And Cardiovascular Surgery Osaka Medical College
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Fukumoto Hitoshi
Department Of Emergency Medicine Osaka Mishima Emergency And Critical Care Center
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Morita Hiroshi
Department Of Applied Physics Graduate School Of Engineering The University Of Tokyo:crest Japan Sci
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Takeshita Hitoshi
Department Of Emergency Medicine Osaka Mishima Emergency And Critical Care Center
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Morita Hiroshi
Department Of Applied Chemistry School Of Engineering Kanagawa University
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Murai Motonobu
First Department Of Internal Medicine Osaka Medical College
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